Published in
Royal Society of Chemistry, Chemical Communications, 36(54), p. 4573-4576
DOI: 10.1039/c8cc01355a
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Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments
Journal article published in 2018 by
Yann Fichou 
,
Michael Vigers ,
Andrew K. Goring ,
Neil A. Eschmann ,
Songi Han
,
Michael Vigers ,
Andrew K. Goring ,
Neil A. Eschmann ,
Songi Han
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Abstract
Tau filaments formed with heparin are structurally different from Alzheimer's disease filaments extracted from human brains. Heparin creates heterogeneous filaments in which tau proteins are locally stretched and have minimal large-domain structuration.