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Royal Society of Chemistry, Journal of Materials Chemistry B: Materials for biology and medicine, 29(5), p. 5816-5834, 2017
DOI: 10.1039/c7tb00481h
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Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma
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Abstract
Using core–shell microparticles encapsulating p53/β-CD-g-CS NPs and nutlin-3a effectively suppressed p53–MDM2 interaction and restored p53 apoptotic activity in cancer cells.