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Royal Society of Chemistry, Chemical Communications, 7(47), p. 2065, 2011

DOI: 10.1039/c0cc05059h

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Protein-Ligand Binding Investigated by a Single Nanoparticle TERS Approach

Journal article published in 2011 by Stacey L. Carrier, Corey M. Kownacki, Zachary D. Schultz ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We report TERS imaging of individual 50-nm, biotin-labeled gold nanoparticles bound to a streptavidin-derivatized glass slide. Individual gold nanoparticles detected by a nanoparticle TERS tip generate Raman enhancements in both the biotin and streptavidin signals. These results indicate that nanoparticles are capable of investigating nanoscale spatial and chemical environments with non-resonant Raman enhancements.