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Royal Society of Chemistry, MedChemComm, 5(9), p. 893-896

DOI: 10.1039/c8md00114f

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Elucidation of fluorine's impact on pKa and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors

Journal article published in 2018 by Kasper Fjelbye ORCID, Mauro Marigo ORCID, Rasmus P. Clausen ORCID, Erling B. Jørgensen, Claus T. Christoffersen ORCID, Karsten Juhl ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The influence of replacing a hydrogen atom with fluorine on the pKa and Pgp-mediated efflux is elucidated for a series of PDE9 inhibitors.