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Royal Society of Chemistry, Physical Chemistry Chemical Physics, 18(20), p. 12664-12677, 2018

DOI: 10.1039/c7cp08623g

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Protein environment affects the water–tryptophan binding mode. MD, QM/MM, and NMR studies of engrailed homeodomain mutants

Journal article published in 2018 by Nad'a Špačková, Zuzana Trošanová, Filip Šebesta, Séverine Jansen, Jaroslav V. Burda ORCID, Pavel Srb ORCID, Milan Zachrdla, Lukáš Žídek ORCID, Jiří Kozelka ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Water molecules can interact with the π-face of tryptophan either forming an O–H⋯π hydrogen bond or by a lone-pair⋯π interaction. Surrounding amino acids can favor the one or the other interaction type.