Published in
Royal Society of Chemistry, Chemical Communications, 95(53), p. 12814-12817
DOI: 10.1039/c7cc07582k
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Synthesis and characterization of the first inhibitor ofN-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)
Journal article published in 2017 by
Beatrice Castellani 
,
Eleonora Diamanti ,
Daniela Pizzirani ,
Piero Tardia ,
Martina Maccesi ,
Natalia Realini ,
Paola Magotti ,
Gianpiero Garau ,
Thomas Bakkum ,
Silvia Rivara ,
Marco Mor ,
Daniele Piomelli
,
Eleonora Diamanti ,
Daniela Pizzirani ,
Piero Tardia ,
Martina Maccesi ,
Natalia Realini ,
Paola Magotti ,
Gianpiero Garau ,
Thomas Bakkum ,
Silvia Rivara ,
Marco Mor ,
Daniele Piomelli
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Abstract
ARN19874 is a quinazolinedione sulfonamide derivative that inhibits NAPE-PLD, a membrane-associated enzyme that cleavesN-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs).