525 papers found
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NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction
Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial
Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay
PARP Inhibitors in Reproductive System Cancers: Current Use and Developments
Longitudinal Transcriptional Response of Glycosylation-Related Genes, Regulators, and Targets in Cancer Cell Lines Treated With 11 Antitumor Agents
Effective implementation of novel MET pharmacodynamic assays in translational studies
The NCI-60 Methylome and Its Integration into CellMiner
Role of adaptive randomization in developing novel therapies for patients with breast cancer
Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A
Abstract IA12: NCI's patient-derived cancer models repository
Theory and practice of clinical pharmacodynamics in oncology drug development
Immuno-pharmacodynamics for evaluating mechanism of action and developing immunotherapy combinations
Establishing proof of mechanism: Assessing target modulation in early-phase clinical trials
The root causes of pharmacodynamic assay failure
Pharmacodynamic endpoints as clinical trial objectives to answer important questions in oncology drug development
Abstract 1456: Dexamethasone suppresses cytokine-induced dual oxidase 2 (Duox2) and VEGF-A expression in human pancreatic cancer cellsin vitroand pancreatic cancer growth in xenografts
Abstract 606: Similar 3D pharmacodynamic (3D-PD) responses of human tumor spheroids and xenografts to topoisomerase 1 inhibitor-induced DNA damage
Abstract 5178: Determinants of response to temozolomide in an exceptionally sensitive patient derived model
Abstract 2809: ROS signaling by NADPH oxidase 5 (Nox5) modulates proliferation of human melanoma UACC-257 cells and prolongs growth in the absence of serum or growth factors
Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment
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