David Umbaugh - Dissemin

All papers authored by David Umbaugh

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2024 David S. Umbaugh

, Nga T. Nguyen, Steven C. Curry, Jody A. Rule, William M. Lee, Anup Ramachandran, Hartmut Jaeschke

The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure

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David S. Umbaugh

, Hartmut Jaeschke

Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight

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2023 Giselle Sanchez-Guerrero

, David S. Umbaugh

, Abhay A. Ramachandran, Antonio Artigues, Hartmut Jaeschke

, Anup Ramachandran

Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose

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Nga T. Nguyen

, David S. Umbaugh

, Sawyer Smith, Olamide B. Adelusi

, Giselle Sanchez-Guerrero

, Anup Ramachandran

, Hartmut Jaeschke

Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice

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2022 Hartmut Jaeschke

, David S. Umbaugh

, Anup Ramachandran

Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity

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David S. Umbaugh

, Rupal P. Soder, Nga T. Nguyen, Olamide Adelusi, Dakota R. Robarts, Ben Woolbright, Luqi Duan, Sunil Abhyankar, Buddhadeb Dawn, Udayan Apte, Hartmut Jaeschke

, Anup Ramachandran

Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts

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David S. Umbaugh

, J. Claire Maciejewski, Joshua S. Wooten, Brianne L. Guilford

Neuronal Inflammation is Associated with Changes in Epidermal Innervation in High Fat Fed Mice

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Hartmut Jaeschke

, David S. Umbaugh

Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis

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Nga T. Nguyen

, David S. Umbaugh

, Eileen L. Huang

, Olamide B. Adelusi

, Giselle Sanchez Guerrero

, Anup Ramachandran

, Hartmut Jaeschke

Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice

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Dakota R. Robarts, Steven R. McGreal, David S. Umbaugh

, Wendena S. Parkes, Manasi Kotulkar, Sarah Abernathy, Norman Lee, Hartmut Jaeschke, Sumedha Gunewardena, Stephen A. Whelan

, John A. Hanover, Natasha E. Zachara, Chad Slawson, Udayan Apte

Regulation of Liver Regeneration by Hepatocyte O-GlcNAcylation in Mice

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Joshua S. Wooten

, Kaylee E. Poole, Matthew P. Harris, Brianne L. Guilford, Megan L. Schaller, David Umbaugh

, Andrew Seija

The effects of voluntary wheel running during weight-loss on biomarkers of hepatic lipid metabolism and inflammation in C57Bl/6J mice

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2021 Hartmut Jaeschke

, Olamide B. Adelusi, Jephte Y. Akakpo

, Nga T. Nguyen, Giselle Sanchez-Guerrero

, David S. Umbaugh

, Wen-Xing Ding, Anup Ramachandran

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

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Ashok Silwal, Austin House, Karin Sandoval, Shaluah Vijeth, David Umbaugh

, Albert Crider, Shirin Mobayen, William Neumann, Ken A. Witt

Novel Somatostatin Receptor-4 Agonist SM-I-26 Mitigates Lipopolysaccharide-Induced Inflammatory Gene Expression in Microglia

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Nga T. Nguyen, David S. Umbaugh

, Giselle Sanchez-Guerrero

, Anup Ramachandran, Hartmut Jaeschke

Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice

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Anup Ramachandran

, David S. Umbaugh

, Hartmut Jaeschke

Mitochondrial Dynamics in Drug-Induced Liver Injury

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David S. Umbaugh

, Anup Ramachandran

, Hartmut Jaeschke

Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing

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David S. Umbaugh

, Nga T. Nguyen, Hartmut Jaeschke

, Anup Ramachandran

Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure

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2020 Nga T. Nguyen, Kuo Du, Jephte Y. Akakpo, David S. Umbaugh

, Hartmut Jaeschke, Anup Ramachandran

Mitochondrial Protein Adduct and Superoxide Generation are Prerequisites for Early Activation of c-Jun N-terminal Kinase within the Cytosol after an Acetaminophen Overdose in Mice

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David S. Umbaugh

, Hartmut Jaeschke

Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity.

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Hartmut Jaeschke

, Jephte Y. Akakpo, David S. Umbaugh

, Anup Ramachandran

Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure

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All papers authored by David Umbaugh