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All papers authored by Romain Guiho

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2024 Than‐Thuy Nham, Romain Guiho

ORCID

, Régis Brion, Jérôme Amiaud, Bénédicte Brounais Le Royer, Anne Gomez‐Brouchet, Françoise Rédini, Hélios Bertin

ORCID

Zoledronic acid enhances tumor growth and metastatic spread in a mouse model of jaw osteosarcoma

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2023 Domhnall McHugh, Bin Sun

ORCID

, Carmen Gutierrez-Muñoz, Fernanda Hernández-González, Massimiliano Mellone

ORCID

, Romain Guiho

ORCID

, Imanol Duran, Joaquim Pombo, Federico Pietrocola, Jodie Birch, Wouter W. Kallemeijn, Sanjay Khadayate, Gopuraja Dharmalingam, Santiago Vernia

ORCID

, Edward W. Tate

ORCID

and 5 other authors

COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells

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Mélina Georget, Anaïs Defois, Romain Guiho

ORCID

, Nina Bon, Sophie Allain, Cécile Boyer, Boris Halgand, Denis Waast, Gaël Grimandi, Alban Fouasson-Chailloux, Jérôme Guicheux, Claire Vinatier

Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes

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Scott Haston, Estela Gonzalez-Gualda, Samir Morsli, Jianfeng Ge, Virinder Reen, Alexander Calderwood, Ilias Moutsopoulos, Leonidas Panousopoulos, Polina Deletic, Gabriela Carreno, Romain Guiho

ORCID

, Saba Manshaei, Jose Mario Gonzalez-Meljem, Hui Yuan Lim, Daniel J. Simpson and 13 other authors

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

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2022 Régis Brion, Malika Gantier

ORCID

, Kevin Biteau, Julien Taurelle, Bénédicte Brounais-Le Royer

ORCID

, Franck Verrecchia

ORCID

, Françoise Rédini, Romain Guiho

ORCID

TRAIL-Based Therapies Efficacy in Pediatric Bone Tumors Models Is Modulated by TRAIL Non-Apoptotic Pathway Activation via RIPK1 Recruitment

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Florian Selt

ORCID

, Romain Sigaud

ORCID

, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alcon, Simone Schmid, Heike Peterziel, Jessica W. Tsai, Romain Guiho

ORCID

, Juan Pedro Martínez-Barbera, Stefan Pusch

ORCID

, Jing Deng, Yifan Zhai, Cornelis M. van Tilburg

ORCID

and 13 other authors

BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma

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Ashley Vardon, Romain Guiho

ORCID

, Diana Carvalho, Jessica Boult, Rebecca Carter, Yura Grabovska, Alan Mackay, Guangrong Zheng, Daohong Zhou, Crispin Hiley, Mark Lythgoe, Chris Jones, Darren Hargrave, Juan-Pedro Martinez

DIPG-46. Radiation induced senescence in diffuse intrinsic pontine glioma cells reveals selective vulnerability to Bcl-XL inhibition

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Daniela Kocher, Florian Selt, Gintvile Valinciute, Julia Zaman, David Vonhören, Stefan Pusch, Romain Guiho

ORCID

, Juan Pedro Martinez-Barbera, Andreas von Deimling, Stefan M. Pfister, David T. W. Jones, Tilman Brummer, Olaf Witt, Till Milde, Romain Sigaud

LGG-17. Preventing recurrence: targeting molecular mechanisms driving tumor growth rebound after MAPKi withdrawal in pediatric low-grade glioma

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2021 Ashley Vardon, Romain Guiho

ORCID

, Diana Carvalho, Chris Jones, Darren Hargrave, Juan-Pedro Martinez-Barbera

HGG-07. Radiation Induced Senescence in Diffuse Intrinsic Pontine Glioma Cells Reveals Selective Vulnerability to BCL-Xl Inhibition

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Romain Guiho

ORCID

, Florian Selt, Thomas Stone, Thomas Jacques, Darren Hargrave, Jesús Gil, Olaf Witt, Till Milde, Juan Pedro Martinez Barbera

LGG-09. Senolytic Agent Navitoclax Targets Vinblastine- And Mapk Inhibitors-Induced Senescent Tumour Cells in Paediatric Low Grade Gliomas

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Florian Selt, Romain Sigaud, Philipp Sievers, Julia Zaman, Heike Peterziel, Jessica W. Tsai, Romain Guiho

ORCID

, Juan Pedro Martínez-Barbera, Stefan Pusch, Martin U. Schuhmann, Stefan M. Pfister, Ahmed El Damaty, Ina Oehme, Pratiti Bandopadhayay, Felix Sahm and 3 other authors

LGG-11. Bh3-Mimetics Targeting BCL-Xl Selectively Impact the Senescent Compartment of Pilocytic Astrocytoma

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2020 Gabriela Carreno

ORCID

, Romain Guiho

ORCID

, Juan Pedro Martinez‐Barbera

ORCID

Cell Senescence in Neuropathology: a Focus on Neurodegeneration and Tumours

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Ana Guerrero, Dominic J. Withers, Romain Guiho

ORCID

, Nicolás Herranz, Anthony Uren, Withers Dj, Martínez Barbera Jp, Juan Pedro Martínez‐Barbera, Tietze Lf, Lutz F. Tietze, Jesús Gil

ORCID

Galactose‐modified duocarmycin prodrugs as senolytics

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2019 Ana Guerrero, Nicolás Herranz, Bin Sun

ORCID

, Verena Wagner, Suchira Gallage

ORCID

, Romain Guiho

ORCID

, Katharina Wolter, Joaquim Pombo, Elaine E. Irvine, Andrew J. Innes

ORCID

ORCID

, Justyna Glegola, Saba Manshaei, Danijela Heide, Gopuraja Dharmalingam and 11 other authors

Cardiac glycosides are broad-spectrum senolytics

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Gabriela Carreno, A. Virasami, Jessica Kr R. Boult, John R. Apps, Jose Mario Gonzalez-Meljem, Scott Haston, Romain Guiho

ORCID

, Christina Stache, L. M. Smith, Laura S. Danielson, L. Panousopoulos, Alexander Koers, M. Buchfelder, T. S. Jacques, L. Chesler and 3 other authors

SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma

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2018 Juliane L. Buhl, Florian Selt, Thomas Hielscher, Romain Guiho

ORCID

, Jonas Ecker, Felix Sahm, Johannes Ridinger, Dennis Riehl, Diren Usta, Britta Ismer, Alexander C. Sommerkamp, J. P. Martinez-Barbera, Annika K. Wefers

ORCID

, Marc Remke, Daniel Picard and 16 other authors

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

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Romain Guiho

ORCID

, Kevin Biteau, Giulia Grisendi, Mathias Chatelais, Regis Brion, Julien Taurelle, Sarah Renault, Dominique Heymann

ORCID

, Massimo Dominici

ORCID

, Françoise Redini

ORCID

In vitro and in vivo discrepancy in inducing apoptosis by mesenchymal stromal cells delivering membrane-bound tumor necrosis factor–related apoptosis inducing ligand in osteosarcoma pre-clinical models

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John Apps, Romaine Guiho

ORCID

, Ying Hong, Darren Hargrave, Paul Brogan, Thomas Jacques, Juan Pedro Martinez-Barbera

Cran-17. Tumour Compartment Transcriptomics Demonstrate the Activation of Inflammatory and Odontogenic Programmes in Human Adamantinomatous Craniopharyngioma and Identify Novel Therapeutic Targets

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John R. Apps, Gabriela Carreno, Jose Mario Gonzalez-Meljem, Scott Haston

ORCID

, Romain Guiho

ORCID

, Julie E. Cooper, Saba Manshaei, Nital Jani, Annett Hölsken, Benedetta Pettorini, Robert J. Beynon, Deborah M. Simpson, Helen C. Fraser, Ying Hong, Shirleen Hallang and 24 other authors

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target

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2017 Louis-Romee Le Nail, Luciano Vidal

ORCID

, Romain Guiho

ORCID

, Clotilde Dumars, Jerome Amiaud, Kevin Biteau, Vincent Crenn, Francoise Redini, Francois Gouin, Anne Moreau, Dominique Heymann, Nail Ll, L. L. Nail

Bone microenvironment has an influence on the histological response of osteosarcoma to chemotherapy: Retrospective analysis and preclinical modeling

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