Christopher Fotsch

All papers authored by Christopher Fotsch

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2024 Christopher Fotsch

, Debaleena Basu, Ryan Case

, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish

, Xiang Yi

, Stephan G. Zech, Peter Hodder

Creating a more strategic small molecule biophysical hit characterization workflow

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2020 Adam Birkholz

, David J. Kopecky, Laurie P. Volak, Michael D. Bartberger

, Yuping Chen, Christopher M. Tegley, Tara Arvedson, John D. McCarter, Christopher Fotsch

, Victor J. Cee

Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution

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2016 John G. Allen, Mirna Mujacic, Michael J. Frohn, Alex J. Pickrell, Paul Kodama, Dhanashri Bagal, Tisha San Miguel, E. Allen Sickmier, Steve Osgood, Aleksander Swietlow, Vivian Li, John B. Jordan, Ki-Won Kim, Anne-Marie C. Rousseau, Yong-Jae Kim and 6 other authors

Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

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2015 Lewis D. Pennington, Michael D. Bartberger, Michael D. Croghan, Kristin L. Andrews, Kate S. Ashton, Matthew P. Bourbeau, Jie Chen, Samer Chmait, Rod Cupples, Christopher Fotsch

, Joan Helmering, Fang-Tsao Hong, Randall W. Hungate, Steven R. Jordan, Ke Kong and 17 other authors

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n_N → σ*_S–X) Interaction for Conformational Constraint

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Victor J. Cee, Laurie P. Volak, Yuping Chen, Michael D. Bartberger, Chris Tegley, Tara Arvedson, John McCarter, Andrew S. Tasker, Christopher Fotsch

Systematic Study of the Glutathione (GSH) Reactivity ofN-Arylacrylamides: 1. Effects of Aryl Substitution

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This paper is available in a repository.

Nuria A. Tamayo, Mark H. Norman, Michael D. Bartberger, Fang-Tsao Hong, Yunxin Bo, Longbin Liu, Nobuko Nishimura, Kevin C. Yang, Seifu Tadesse, Christopher Fotsch

, Jie Chen, Samer Chmait, Rod Cupples, Clarence Hale, Steven R. Jordan and 4 other authors

Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

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2014 Fang-Tsao Hong, Mark H. Norman, Kate S. Ashton, Michael D. Bartberger, Jie Chen, Samer Chmait, Rod Cupples, Christopher Fotsch

, Steven R. Jordan, David J. Lloyd, Glenn Sivits, Seifu Tadesse, Clarence Hale, David J. St Jean

Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket

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This paper was not found in any repository; the policy of its publisher is unknown or unclear.

D. J. St Jean, K. S. Ashton, M. D. Bartberger, J. Chen, S. Chmait, R. Cupples, E. Galbreath, J. Helmering, S. R. Jordan, L. Liu, K. Kunz, K. Michelsen, N. Nishimura, L. D. Pennington, S. F. Poon and 9 other authors

Human GKRP bound to AMG-5980 and S6P

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Nobuko Nishimura, Mark H. Norman, Longbin Liu, Kevin C. Yang, Kate S. Ashton, Michael D. Bartberger, Samer Chmait, Jie Chen, Rod Cupples, Christopher Fotsch

, Joan Helmering, Steven R. Jordan, Roxanne K. Kunz, Lewis D. Pennington, Steve F. Poon and 5 other authors

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N -Arylsulfonamido- N ′-arylpiperazine Series

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K. S. Ashton, K. L. Andrews, M. C. Bryan, J. Chen, K. Chen, M. Chen, S. Chmait, M. Croghan, R. Cupples, C. Fotsch

, J. Helmering, S. R. Jordan, R. J. Kurzeja, K. Michelsen, L. D. Pennington and 9 other authors

Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate

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Kate S. Ashton, Kristin L. Andrews, Marian C. Bryan, Jie Chen, Kui Chen, Michelle Chen, Samer Chmait, Michael Croghan, Rod Cupples, Christopher Fotsch

, Joan Helmering, Steve R. Jordan, Robert J. M. Kurzeja, Klaus Michelsen, Lewis D. Pennington and 9 other authors

Correction to Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

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Kate S. Ashton, Kristin L. Andrews, Marion C. Bryan, Jie Chen, Kui Chen, Michelle Chen, Samer Chmait, Michael Croghan, Rod Cupples, Christopher Fotsch

, Joan Helmering, Steve R. Jordan, Robert J. M. Kurzeja, Klaus Michelsen, Lewis D. Pennington and 9 other authors

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

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David J. St Jean, Kate S. Ashton, Michael D. Bartberger, Jie Chen, Samer Chmait, Rod Cupples, Elizabeth Galbreath, Joan Helmering, Fang-Tsao Hong, Steven R. Jordan, Longbin Liu, Roxanne K. Kunz, Klaus Michelsen, Nobuko Nishimura, Lewis D. Pennington and 13 other authors

Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles

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2013 Matthew P. Bourbeau, Aaron Siegmund, John G. Allen, Hong Shu, Christopher Fotsch

, Michael D. Bartberger, Ki-Won Kim, Renee Komorowski, Melissa Graham, James Busby, Minghan Wang, James Meyer, Yang Xu, Kevin Salyers, Mark Fielden and 2 other authors

Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase

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Paul M. Wehn, Paul E. Harrington, Timothy J. Carlson, James Davis, Pierre Deprez, Christopher H. Fotsch

, Mark P. Grillo, Jenny Ying-Lin Lu, Sean Morony, Kanaka Pattabiraman, Steve F. Poon, Jeff D. Reagan, David J. St. Jean, Taoues Temal, Minghan Wang and 3 other authors

Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism

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Paul E. Harrington, Matthew P. Bourbeau, Christopher Fotsch