Severin Mairinger

All papers authored by Severin Mairinger

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2024 Severin Mairinger

, Matthias Jackwerth, Ondřej Soukup, Matthias Blaickner, Clemens Decristoforo, Lukas Nics, Jens Pahnke, Marcus Hacker, Markus Zeitlinger, Oliver Langer

Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates

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Thomas Wanek

, Marco Raabe

, Md Noor A. Alam, Thomas Filip, Johann Stanek, Mathilde Loebsch, Christian Laube

, Severin Mairinger

, Tanja Weil, Claudia Kuntner

Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities

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Irene Hernández-Lozano, Sarah Leterrier, Severin Mairinger

, Johann Stanek, Anna S. Zacher, Lara Breyer, Marcus Hacker, Markus Zeitlinger, Jens Pahnke, Nicolas Tournier, Thomas Wanek, Oliver Langer

Performance and Sensitivity of [^99mTc]Tc-sestamibi Compared with Positron Emission Tomography Radiotracers to Measure P-glycoprotein Function in the Kidneys and Liver

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2023 Myriam El Biali, Sylvain Auvity, Salvatore Cisternino, Maria Smirnova, Marcus Hacker, Markus Zeitlinger, Severin Mairinger

, Nicolas Tournier, Martin Bauer, Oliver Langer

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Severin Mairinger

, Sarah Leterrier, Thomas Filip, Mathilde Löbsch, Jens Pahnke, Irene Hernández-Lozano, Johann Stanek, Nicolas Tournier, Markus Zeitlinger, Marcus Hacker, Oliver Langer, Thomas Wanek

[¹¹C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier

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Severin Mairinger

, Irene Hernández-Lozano, Lena Zachhuber, Thomas Filip, Mathilde Löbsch, Markus Zeitlinger, Marcus Hacker, Carsten Ehrhardt, Oliver Langer

Effect of budesonide on pulmonary activity of multidrug resistance-associated protein 1 assessed with PET imaging in rats

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Severin Mairinger

, Irene Hernández-Lozano, Thomas Filip, Mathilde Löbsch, Johann Stanek, Markus Zeitlinger, Marcus Hacker, Nicolas Tournier, Thomas Wanek, Carsten Ehrhardt, Oliver Langer

Influence of P-glycoprotein on pulmonary disposition of the model substrate [11C]metoclopramide assessed by PET imaging in rats

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Irene Hernández-Lozano, Severin Mairinger

, Thomas Filip, Mathilde Löbsch, Johann Stanek, Claudia Kuntner, Martin Bauer, Markus Zeitlinger

, Marcus Hacker, Thomas H. Helbich, Thomas Wanek, Oliver Langer

Positron Emission Tomography-Based Pharmacokinetic Analysis To Assess Renal Transporter-Mediated Drug-Drug Interactions of Antimicrobial Drugs

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Johannes A. Sake, Mohammed Ali Selo, Lyubomyr Burtnyak, Henriette E. Dähnhardt, Camelia Helbet, Severin Mairinger

, Oliver Langer, Vincent P. Kelly

, Carsten Ehrhardt

Knockout of ABCC1 in NCI-H441 cells reveals CF to be a suboptimal substrate to study MRP1 activity in organotypic in vitro models

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Thomas Wanek, Severin Mairinger

, Marco Raabe

, Md Noor A. Alam, Thomas Filip, Johann Stanek, Gordon Winter, Lujuan Xu, Christian Laube, Tanja Weil, Volker Rasche, Claudia Kuntner

Synthesis, radiolabeling, and preclinical in vivo evaluation of 68Ga-radiolabelled nanodiamonds

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2022 Severin Mairinger

, Irene Hernández-Lozano, Markus Zeitlinger, Carsten Ehrhardt

, Oliver Langer

Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition

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Severin Mairinger

, Irene Hernández-Lozano, Thomas Filip, Michael Sauberer, Mathilde Löbsch, Johann Stanek, Thomas Wanek, Johannes A. Sake, Thomas Pekar, Carsten Ehrhardt, Oliver Langer

Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats

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Michael Wölfl-Duchek, Severin Mairinger

, Irene Hernández-Lozano

, Thomas Filip, Viktoria Zoufal, Mathilde Löbsch, Johann Stanek, Claudia Kuntner

, Thomas Wanek, Martin Bauer

, Jens Pahnke

, Oliver Langer

Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice

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Irene Hernández-Lozano, Severin Mairinger

, Thomas Filip, Michael Sauberer, Thomas Wanek, Johann Stanek, Johannes A. Sake, Thomas Pekar, Carsten Ehrhardt, Oliver Langer

PET imaging to assess the impact of P-glycoprotein on pulmonary drug delivery in rats

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2021 Thomas Filip, Severin Mairinger

, Joerg Neddens, Michael Sauberer, Stefanie Flunkert

, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner

Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling

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Irene Hernández-Lozano

, Severin Mairinger

, Alexander Traxl, Michael Sauberer, Thomas Filip, Johann Stanek

, Claudia Kuntner, Thomas Wanek

, Oliver Langer

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice

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Irene Hernández-Lozano

, Thomas Wanek

, Michael Sauberer

, Thomas Filip, Severin Mairinger

, Johann Stanek

, Alexander Traxl, Rudolf Karch

, John D. Schuetz, Oliver Langer

Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice

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Irene Hernández-Lozano, Severin Mairinger

, Michael Sauberer, Johann Stanek, Thomas Filip, Thomas Wanek, Giuliano Ciarimboli, Nicolas Tournier, Oliver Langer

Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice

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2020 Thomas Wanek

, Viktoria Zoufal, Mirjam Brackhan, Markus Krohn

, Severin Mairinger

, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Pekar, Jens Pahnke

, Oliver Langer

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

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Nicolas Tournier, Sebastien Goutal, Severin Mairinger

, Irene Hernández-Lozano, Irene H. Lozano, Thomas Filip, Michael Sauberer, Fabien Caillé, Louise Breuil, Johann Stanek, Anna F. Freeman, Gaia Novarino, Charles Truillet, Thomas Wanek, Oliver Langer

Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib

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All papers authored by Severin Mairinger