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All papers authored by Adam J. Fletcher

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2024 Christopher Green, Konstanze F. Winklhofer, Adam J. Fletcher

ORCID

, Leo C. James, John Skidmore, James Duce, William A. McEwan

Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains

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2021 Juraj Ahel

ORCID

, Adam Fletcher

ORCID

, Daniel B. Grabarczyk, Elisabeth Roitinger, Luiza Deszcz, Anita Lehner, Satpal Virdee, Tim Clausen

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

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Virginia De Cesare, Daniel Carbajo Lopez, Peter D. Mabbitt

ORCID

, Adam J. Fletcher

ORCID

, Mathieu Soetens

ORCID

, Odetta Antico, Nicola T. Wood, Satpal Virdee

ORCID

Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases

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2020 Peter D. Mabbitt

ORCID

, Andrea Loreto, Marc-André Déry, Adam J. Fletcher

ORCID

, Mathew Stanley

ORCID

, Kuan-Chuan Pao, Nicola T. Wood, Michael P. Coleman, Satpal Virdee

ORCID

Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity

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Sunil Mathur, Adam J. Fletcher

ORCID

, Emma Branigan, Ronald T. Hay, Satpal Virdee

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases

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2019 Donna L. Mallery, K. M. Rifat Faysal, Alex Kleinpeter, Miranda S. C. Wilson, Marina Vaysburd, Adam J. Fletcher

ORCID

, Mariia Novikova, Till Böcking, Eric O. Freed, Adolfo Saiardi, Leo C. James

Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication

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2018 Adam J. Fletcher

ORCID

, Marina Vaysburd, Sarah Maslen, Jingwei Zeng, J. Mark Skehel, Greg J. Towers

ORCID

, Leo C. James

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

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Claire Dickson, Adam J. Fletcher

ORCID

, Marina Vaysburd, Ji-Chun Yang, Donna L. Mallery, Jingwei Zeng, Christopher M. Johnson, Stephen H. McLaughlin

ORCID

, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W. Chin, David Neuhaus, Leo C. James

ORCID

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

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2016 Adam J. Fletcher

ORCID

, Leo C. James

Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21

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2015 Adam J. Fletcher

ORCID

, Donna L. Mallery, Ruth E. Watkinson

ORCID

, Claire F. Dickson, Leo C. James

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

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Adam J. Fletcher

ORCID

, Devin E. Christensen, Chad Nelson, Choon Ping Tan, Torsten Schaller

ORCID

, Paul J. Lehner, Wesley I. Sundquist, Greg J. Towers

ORCID

TRIM 5α requires Ube2W to anchor Lys63‐linked ubiquitin chains and restrict reverse transcription

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2014 Amanda J. Price, David A. Jacques, William A. McEwan

ORCID

, Adam J. Fletcher

ORCID

, Sebastian Essig, Jason W. Chin, Upul D. Halambage, Christopher Aiken, Leo C. James

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

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Db Guiliano, Helen Fussell, Izabela Lenart, Edward Tsao, Darren Nesbeth, Aj Fletcher

ORCID

, Ec Campbell, Nasim Yousaf, Sarah Williams, Susana Santos, Amy Cameron, Gj Towers

ORCID

, Paul Kellam, Dn Hebert, Kg Gould and 2 other authors

Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation.

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2013 Adam J. Fletcher

ORCID

, Greg J. Towers

ORCID

Inhibition of Retroviral Replication by Members of the TRIM Protein Family

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Jane Rasaiyaah, Choon Ping Tan, Choon Ping Tan, Adam J. Fletcher

ORCID

, Amanda J. Price, Caroline Blondeau, Laura Hilditch, David A. Jacques, David L. Selwood, Leo C. James, Mahdad Noursadeghi, Greg J. Towers

ORCID

HIV-1 evades innate immune recognition through specific cofactor recruitment

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2012 KewalRamani Vn, Amanda J. Price, Price Aj, Adam J. Fletcher

ORCID

, Fletcher Aj, Torsten Schaller

ORCID

, Tom Elliott, KyeongEun Lee, Vineet N. KewalRamani, Chin Jw, Jason W. Chin, Towers Gj, Greg J. Towers, Leo C. James, Hans-Georg Krausslich and 1 other authors

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

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2011 Torsten Schaller

ORCID

, Karen E. Ocwieja, Jane Rasaiyaah, Amanda J. Price, Troy L. Brady, Shoshannah L. Roth, Stéphane Hué

ORCID

, Adam J. Fletcher

ORCID

, KyeongEun Lee, Vineet N. KewalRamani, Mahdad Noursadeghi, Richard G. Jenner, Leo C. James, Frederic D. Bushman, Greg J. Towers

ORCID

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

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2010 Aj Fletcher

ORCID

, Stéphane Hue

ORCID

, Torsten Schaller

ORCID

, Deenan Pillay, Gj Towers

ORCID

Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related lagomorpha TRIM5 genes.

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2008 Laura M. J. Ylinen, Torsten Schaller

ORCID

, Amanda Price, Adam J. Fletcher

ORCID

, Mahdad Noursadeghi, Leo C. James, Greg J. Towers

ORCID

Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D

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Ekaterina Lyulcheva, Eleanor Taylor, Magdalene Michael

ORCID

, Anne Vehlow, Shengjiang Tan, Matthias Krause, Jill Gosney, Adam Fletcher

ORCID

, Daimark Bennett

ORCID

Drosophila Pico and Its Mammalian Ortholog Lamellipodin Activate Serum Response Factor and Promote Cell Proliferation

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