Dong Lu
0000-0002-9919-6378
Baylor College of Medicine
19 papers found
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Development of Biochemical and Cellular Probes to Study RIPK1 Target Engagement
Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy
Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors
Targeted Protein Degradation via Lysosomes
Discovery of a potent BTK and IKZF1/3 triple degrader through reversible covalent BTK PROTAC development
Applications of covalent chemistry in targeted protein degradation
Development of improved SRC-3 inhibitors as breast cancer therapeutic agents
Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry
Discovery of Phthalazinone Derivatives as Novel Hepatitis B Virus Capsid Inhibitors
Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors
Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives
Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors
Optimization and Synthesis of Pyridazinone Derivatives as Novel Inhibitors of Hepatitis B Virus by Inducing Genome-free Capsid Formation
Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors
Pyridazinone Derivatives Displaying Highly Potent and Selective Inhibitory Activities against c-Met Tyrosine Kinase
A Novel Pyridazinone Derivative Inhibits Hepatitis B Virus Replication by Inducing Genome-Free Capsid Formation
Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors
Copper(I)-Mediated Cascade Reactions: An Efficient Approach to the Synthesis of Functionalized Benzofuro[3,2-d]pyrimidines
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