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All papers authored by Klas Wiman

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2024 Charlotte Strandgren

ORCID

, Klas G. Wiman

ORCID

Therapeutic targeting of TP53 nonsense mutations in cancer

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2023 Amos Tuval

ORCID

, Charlotte Strandgren

ORCID

, Angelos Heldin, Mireia Palomar-Siles, Klas G. Wiman

ORCID

Pharmacological reactivation of p53 in the era of precision anticancer medicine

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Mireia Palomar-Siles

ORCID

, Viktor Yurevych

ORCID

, Vladimir J. N. Bykov, Klas G. Wiman

ORCID

Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

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Angelos Heldin, Matko Cancer, Mireia Palomar-Siles, Susanne Öhlin, Meiqiongzi Zhang, Alexander Sun-Zhang, Anna Mariani, Jianping Liu, Vladimir J. N. Bykov, Klas G. Wiman

ORCID

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

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2022 Qiang Zhang, Dimitrios-Ilias Balourdas

ORCID

, Bruno Baron, Alon Senitzki, Tali E. Haran

ORCID

, Klas G. Wiman

ORCID

, Thierry Soussi

ORCID

, Andreas C. Joerger

ORCID

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

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2020 Sophia Ceder

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, Sofi E. Eriksson

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, Emarndeena H. Cheteh

ORCID

ORCID

, Mariana Corrales Benitez, Vladimir J. N. Bykov

ORCID

, Kenji M. Fujihara

ORCID

, Mélodie Grandin

ORCID

ORCID

ORCID

, Corina Behrenbruch, Kaylene J. Simpson

ORCID

, Frédéric Hollande

ORCID

, Lars Abrahmsen, Nicholas J. Clemons

ORCID

and 1 other authors

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

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Flora Doffe, Vincent Carbonnier, Manon Tissier, Bernard Leroy, Isabelle Martins, Johanna S. M. Mattsson, Patrick Micke, Sarka Pavlova, Sarka Pospisilova, Jana Smardova, Andreas C. Joerger, Klas G. Wiman

ORCID

, Guido Kroemer, Thierry Soussi

ORCID

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

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2019 Qiang Zhang, Vladimir J. N. Bykov

ORCID

, Klas G. Wiman

ORCID

, Joanna Zawacka-Pankau

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

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2018 Lena Haffo, Jun Lu, Vladimir J. N. Bykov

ORCID

, Sebastin S. Martin, Xiaoyuan Ren, Lucia Coppo, Klas G. Wiman

ORCID

, Arne Holmgren

ORCID

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

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Meiqiongzi Zhang, Angelos Heldin, Mireia Palomar-Siles, Susanne Öhlin, Vladimir J. N. Bykov, Klas G. Wiman

ORCID

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

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2017 Vladimir J. N. Bykov, Sofi E. Eriksson, Julie Bianchi, Klas G. Wiman

ORCID

Targeting mutant p53 for efficient cancer therapy

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Qiang Zhang, Vladimir J. N. Bykov

ORCID

, Klas G. Wiman

ORCID

, Joanna Zawacka-Pankau

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

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Emarndeena H. Cheteh, Martin Augsten, Helene Rundqvist, Julie Bianchi, Victoria Sarne, Lars Egevad, Vladimir Jn Bykov, Arne Östman, Klas G. Wiman

ORCID

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

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Weicheng Ren

ORCID

, Xiaofei Ye, Hong Su, Wei Li, Dongbing Liu, Mohammad Pirmoradian, Xianhuo Wang, Bo Zhang, Qiang Zhang, Longyun Chen, Man Nie, Yao Liu, Bin Meng, Huiqiang Huang, Wenqi Jiang and 10 other authors

Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma

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K. G. Wiman

ORCID

, B. Zhivotovsky

ORCID

Introduction to Nobel Conference: ‘The Cell Cycle and Cell Death in Disease’

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K. G. Wiman

ORCID

, B. Zhivotovsky

ORCID

Understanding cell cycle and cell death regulation provides novel weapons against human diseases

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David S. Liu, Cuong P. Duong, Sue Haupt, Karen G. Montgomery, Colin M. House, Walid J. Azar, Helen B. Pearson, Oliver M. Fisher, Matthew Read, Glen R. Guerra

ORCID

, Ygal Haupt, Carleen Cullinane, Klas G. Wiman

ORCID

, Lars Abrahmsen, Wayne A. Phillips

ORCID

and 1 other authors

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

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2016 Åsa Fransson, Daria Glaessgen, Jessica Alfredsson, Klas G. Wiman

ORCID

, Svetlana Bajalica-Lagercrantz, Nina Mohell

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

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Harsha S. Madapura, Daniel Salamon, Klas G. Wiman

ORCID

, Sonia Lain, Eva Klein, Noémi Nagy

cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response

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Vladimir J. N. Bykov, Qiang Zhang, Meiqiongzi Zhang, Sophia Ceder, Lars Abrahmsen, Klas G. Wiman

ORCID

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

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