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All papers authored by John Ellis

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2022 David A. Candito

ORCID

, Vladimir Simov, Anmol Gulati

ORCID

, Solomon Kattar

ORCID

, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot

ORCID

, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor

ORCID

ORCID

, Gregori J. Morriello, John J. Acton, Barbara Pio and 31 other authors

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease

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2021 Philip R. D. Murray

ORCID

, Willem M. M. Bussink, Geraint H. M. Davies

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, Farid W. van der Mei

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, Alyssa H. Antropow

ORCID

, Jacob T. Edwards

ORCID

, Laura Akullian D’Agostino

ORCID

, J. Michael Ellis

ORCID

, Lawrence G. Hamann

ORCID

, Fedor Romanov-Michailidis

ORCID

, Robert R. Knowles

ORCID

Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes

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Marco A. S. Baptista

ORCID

, Kalpana Merchant, Ted Barrett

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, Sakshi Bhargava

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, Dianne K. Bryce

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, J. Michael Ellis

ORCID

, Anthony A. Estrada, Matthew J. Fell, Brian K. Fiske

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, Reina N. Fuji

ORCID

, Paul Galatsis

ORCID

, Anastasia G. Henry

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, Sue Hill

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, Warren Hirst, Christopher Houle

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and 18 other authors

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

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2019 Philip P. Chamberlain

ORCID

, Laura A. D’Agostino

ORCID

, J. Michael Ellis

ORCID

, Joshua D. Hansen

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, Mary E. Matyskiela, Joseph J. McDonald, Jennifer R. Riggs

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, Lawrence G. Hamann

ORCID

Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality

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Noah B. Bissonnette

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, J. Michael Ellis

ORCID

, Lawrence G. Hamann, Fedor Romanov-Michailidis

ORCID

Expedient access to saturated nitrogen heterocycles by photoredox cyclization of imino-tethered dihydropyridines

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2018 Tony Siu

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, Michael D. Altman, Gretchen A. Baltus, Matthew Childers, J. Michael Ellis

ORCID

, Hakan Gunaydin, Harold Hatch, Thu Ho, James Jewell, Brian M. Lacey, Charles A. Lesburg, Bo-Sheng Pan, Berengere Sauvagnat, Gottfried K. Schroeder, Serena Xu

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

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Marco Baptista, Kalpana Merchant, Anthony Estrada, Matthew Fell, Brian Fiske, Reina Fuji, Paul Galatsis

ORCID

, Anastasia Henry, Sue Hill, Warren Hirst, Christopher Houle, Matthew Kennedy, Xingrong Liu, Matthew Maddess, Carrie Markgraf and 17 other authors

LRRK2 kinase inhibitors induce a reversible effect in the lungs of non-human primates with no measurable pulmonary deficits

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Hakan Gunaydin

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, Michael D. Altman, J. Michael Ellis

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, Peter Fuller, Scott A. Johnson, Brian Lahue, Blair Lapointe

Strategy for Extending Half-life in Drug Design and Its Significance

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2017 Cristina St. Pierre, Jane Guo, John D. Shin, Laura W. Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J. Michael Ellis

ORCID

, Hani Houshyar, Michael A. Crackower, Melanie A. Kleinschek, Dallas C. Jones and 4 other authors

A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system

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2016 J. Michael Ellis

ORCID

, Michael D. Altman, Brandon Cash, Andrew M. Haidle, Rachel L. Kubiak, Matthew L. Maddess, Youwei Yan, Alan B. Northrup

Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization

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2015 Matthew J. Fell, Christian Mirescu, Kallol Basu, Boonlert Cheewatrakoolpong, Duane E. DeMong, J. Michael Ellis

ORCID

, J. Michael Ellis, Lynn A. Hyde, Yinghui Lin, Carrie G. Markgraf, Hong Mei, Michael Miller, Frederique M. Poulet, Jack D. Scott, Michelle D. Smith and 5 other authors

MLi-2, a potent, selective and centrally active compound for exploring the therapeutic potential and safety of LRRK2 kinase inhibition

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J. Michael Ellis

ORCID

, Michael D. Altman, Alan Bass, John W. Butcher, Alan J. Byford, Anthony Donofrio, Sheila Galloway, Andrew M. Haidle, James Jewell, Nancy Kelly, Erica K. Leccese, Sandra Lee, Matthew Maddess, J. Richard Miller, Lily Y. Moy and 11 other authors

Overcoming Mutagenicity and Ion Channel Activity: Optimization of Selective Spleen Tyrosine Kinase Inhibitors

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2013 Lily Y. Moy, Yanlin Jia, Michael Caniga, Gissela Lieber, Malgorzata Gil, Xiomara Fernandez, Erich Sirkowski, Richard Miller, Jessica P. Alexander, Hyun-Hee Lee, John D. Shin, J. Michael Ellis

ORCID

, J. Michael Ellis, Hongmin Chen, Alan Wilhelm and 10 other authors

Inhibition of Spleen Tyrosine Kinase Attenuates Allergen-Mediated Airway Constriction

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2009 Travis B. Dunn, J. Michael Ellis

ORCID

, J. Michael Ellis, Christiane C. Kofink, James R. Manning, Larry E. Overman

Asymmetric Construction of Rings A–D of Daphnicyclidin Type Alkaloids

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Michael T Crimmins, J. Michael Ellis

ORCID

, Kyle A Emmitte, Pamela A Haile, Patrick J McDougall, Jonathan D Parrish, J. Lucas Zuccarello

Enantioselective Total Synthesis of Brevetoxin A: Unified Strategy for the B, E, G, and J Subunits

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Michael T. Crimmins, J. Lucas Zuccarello, J. Lucas Zuccarello, Patrick J. McDougall, J. Michael Ellis

ORCID

, J. Michael Ellis

Enantioselective Total Synthesis of Brevetoxin A: Convergent Coupling Strategy and Completion

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2008 Michael T. Crimmins, J. Lucas Zuccarello, J. Lucas Zuccarello, J. Michael Ellis

ORCID

, J. Michael Ellis, Patrick J. McDougall, Pamela A. Haile, Jonathan D. Parrish, Kyle A. Emmitte

Total Synthesis of Brevetoxin A

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J. Michael Ellis

ORCID

, Larry E. Overman, Huw R. Tanner, Jocelyn Wang

A Versatile Synthesis of Unsymmetrical 3,3′-Bioxindoles: Stereoselective Mukaiyama Aldol Reactions of 2-Siloxyindoles with Isatins

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J. Michael Ellis

ORCID

, Joseph Jankovic, L. Giselle Aguilar, Matthew J. Fell

Current approaches to the treatment of Parkinson’s disease

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