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All papers authored by Jean-Marc Taymans

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2024 Yahaira Naaldijk

ORCID

, Belén Fernández

ORCID

, Rachel Fasiczka, Elena Fdez, Coline Leghay, Ioana Croitoru, John B. Kwok, Yanisse Boulesnane, Amelie Vizeneux, Eugenie Mutez, Camille Calvez, Alain Destée, Jean-Marc Taymans

ORCID

, Ana Vinagre Aragon

ORCID

, Alberto Bergareche Yarza and 9 other authors

A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

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2023 Lucia Iannotta, Marco Emanuele, Giulia Favetta, Giulia Tombesi, Laurine Vandewynckel, Antonio Jesús Lara Ordóñez, Jean-Michel Saliou, Matthieu Drouyer, William Sibran, Laura Civiero, R. Jeremy Nichols, Panagiotis S. Athanasopoulos, Arjan Kortholt, Marie-Christine Chartier-Harlin, Elisa Greggio and 1 other authors

PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation

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Jean-Marc Taymans

ORCID

, Matt Fell, Tim Greenamyre, Warren D. Hirst

ORCID

, Adamantios Mamais

ORCID

, Shalini Padmanabhan, Inga Peter

ORCID

, Hardy Rideout, Avner Thaler

Perspective on the current state of the LRRK2 field

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This paper is made freely available by the publisher.

Jean-Marc Taymans

ORCID

, Eugénie Mutez, William Sibran, Laurine Vandewynckel, Claire Deldycke, Séverine Bleuse, Antoine Marchand

ORCID

, Alessia Sarchione, Alexandre Kreisler, Clémence Simonin, James Koprich, Guillaume Baille, Coline Leghay, Luc Defebvre, Kathy Dujardin

ORCID

and 2 other authors

Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers

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2022 Ilda Coku

ORCID

, Eugénie Mutez

ORCID

, Sabiha Eddarkaoui, Sébastien Carrier, Antoine Marchand, Claire Deldycke, Liesel Goveas

ORCID

, Guillaume Baille, Mélissa Tir

ORCID

, Romain Magnez

ORCID

ORCID

, Gaëlle Vermeersch, Wim Vandenberghe

ORCID

ORCID

ORCID

and 4 other authors

Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson′s Disease

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Antoine Marchand

ORCID

, Alessia Sarchione, Panagiotis S. Athanasopoulos

ORCID

, Hélène Bauderlique-Le Roy, Liesel Goveas

ORCID

, Romain Magnez

ORCID

, Matthieu Drouyer, Marco Emanuele, Franz Y. Ho, Maxime Liberelle

ORCID

, Patricia Melnyk

ORCID

, Nicolas Lebègue

ORCID

ORCID

, R. Jeremy Nichols, R. Jeremy Nichols and 5 other authors

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

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Susanna Cogo, Franz Y. Ho, Elena Tosoni, James E. Tomkins, Isabella Tessari, Lucia Iannotta, Thomas J. Montine, Claudia Manzoni, Patrick A. Lewis, Luigi Bubacco, Marie-Christine Chartier Harlin, Jean-Marc Taymans

ORCID

, Arjan Kortholt, Jeremy Nichols, Laura Cendron and 2 other authors

The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation

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2021 Alessia Sarchione, Antoine Marchand, Jean-Marc Taymans

ORCID

, Marie-Christine Chartier-Harlin

ORCID

Alpha-Synuclein and Lipids: The Elephant in the Room?

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Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau and 5 other authors

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

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Noémie Cresto, Camille Gardier, Marie-Claude Gaillard, Francesco Gubinelli, Pauline Roost, Daniela Molina, Charlène Josephine, Noëlle Dufour, Gwenaëlle Auregan, Martine Guillermier, Suéva Bernier, Caroline Jan, Pauline Gipchtein, Philippe Hantraye, Marie-Christine Chartier-Harlin and 7 other authors

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo

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Jean-Marc Taymans

ORCID

Specialty Grand Challenge for Molecular Signalling and Pathways in Molecular Neuroscience

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Liesel Goveas

ORCID

, Eugénie Mutez, Marie-Christine Chartier-Harlin, Jean-Marc Taymans

ORCID

Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells

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2020 Evy Lobbestael, Chris Van den Haute, Francesca Macchi, Jean-Marc Taymans

ORCID

, Veerle Baekelandt

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity

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Hardy J. Rideout, Marie-Christine Chartier-Harlin, Matthew J. Fell, Warren D. Hirst, Sarah Huntwork-Rodriguez, Cheryl E. G. Leyns, Omar S. Mabrouk, Jean-Marc Taymans

ORCID

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

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Antoine Marchand, Matthieu Drouyer, Alessia Sarchione, Marie-Christine Chartier-Harlin, Jean-Marc Taymans

ORCID

LRRK2 Phosphorylation, More Than an Epiphenomenon

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N. Cresto, C. Gardier, M.-C. Gaillard, F. Gubinelli, P. Roost, D. Molina, C. Joséphine, N. Dufour, G. Aurégan, M. Guillermier, S. Bernier, C. Jan, P. Gipchtein, P. Hantraye, M.-C. Chartier-Harlin and 7 other authors

The C-terminal fragment of LRRK2 with the G2019S substitution increases the neurotoxicity of mutant A53T α-synuclein in dopaminergic neurons in vivo

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2019 Belén Fernández, Antonio Jesús Lara Ordóñez, Elena Fdez, Eugénie Mutez, Thomas Comptdaer, Coline Leghay, Alexandre Kreisler, Clémence Simonin, Laurine Vandewynckel, Luc Defebvre, Alain Destée, Séverine Bleuse, Jean-Marc Taymans

ORCID

, Marie-Christine Chartier-Harlin, Sabine Hilfiker

ORCID

Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

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2018 Jean-Marc Taymans

ORCID

, Marie-Christine Chartier-Harlin

In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins

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Jesús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J. Lara Ordóñez, Marian Blanca Ramírez, Patricia Gómez-Suaga, Dieter Waschbüsch, Evy Lobbestael, Veerle Baekelandt, Angus C. Nairn, Javier Ruiz-Martínez, Ana Aiastui, Adolfo López de Munain, Pawel Lis

ORCID

, Thomas Comptdaer and 7 other authors

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

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