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All papers authored by Mallika Singh

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2024 Jingjing Jiang

ORCID

, Lingyan Jiang

ORCID

, Benjamin J. Maldonato

ORCID

ORCID

, Matthew Holderfield

ORCID

ORCID

, Ian P. Winters

ORCID

ORCID

, Cristina Blaj

ORCID

ORCID

, Jens Brodbeck

ORCID

, Zhe Chen

ORCID

, Xing Wei

ORCID

, Michael J. Rosen

ORCID

, Yevgeniy Gindin

ORCID

and 22 other authors

Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

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Matthew Holderfield, Bianca J. Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J. Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart

ORCID

ORCID

, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang and 39 other authors

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

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2023 Heng Du

ORCID

ORCID

, Heng-Jia Liu, Min Yuan, John M. Asara

ORCID

, Kwok-Kin Wong, Elizabeth P. Henske

ORCID

, Mallika Singh

ORCID

, David J. Kwiatkowski

ORCID

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1

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2022 G. Leslie Burnett

ORCID

, Yu C. Yang, James B. Aggen

ORCID

, Jennifer Pitzen, Micah K. Gliedt, Chris M. Semko, Abby Marquez, James W. Evans, Gang Wang, Walter S. Won, Aidan C. A. Tomlinson

ORCID

, Gert Kiss, Christos Tzitzilonis, Arun P. Thottumkara, James Cregg and 14 other authors

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors

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2021 Bianca J. Lee, Jacob A. Boyer, G. Leslie Burnett

ORCID

, Arun P. Thottumkara, Nidhi Tibrewal, Stacy L. Wilson, Tientien Hsieh, Abby Marquez, Edward G. Lorenzana, James W. Evans, Laura Hulea

ORCID

, Gert Kiss, Hui Liu, Dong Lee, Ola Larsson

ORCID

and 11 other authors

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth

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2019 Savithri Ramurthy

ORCID

, Benjamin R. Taft, Robert J. Aversa

ORCID

, Paul A. Barsanti, Matthew T. Burger, Yan Lou, Gisele A. Nishiguchi, Alice Rico, Lina Setti, Aaron Smith, Sharadha Subramanian, Victoriano Tamez, Huw Tanner, Lifeng Wan, Cheng Hu and 33 other authors

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

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2018 Robert J. Nichols, Franziska Haderk, Carlos Stahlhut, Christopher J. Schulze, Golzar Hemmati, David Wildes, Christos Tzitzilonis, Kasia Mordec, Abby Marquez, Jason Romero, Tientien Hsieh, Aubhishek Zaman, Victor Olivas, Caroline McCoach, Collin M. Blakely and 8 other authors

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

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Wenlin Shao, Yuji M. Mishina, Yun Feng, Giordano Caponigro, Vesselina G. Cooke, Stacy Rivera, Yingyun Wang, Fang Shen, Joshua M. Korn, Lesley A. Mathews Griner, Gisele Nishiguchi, Alice Rico, John Tellew, Jacob R. Haling, Robert Aversa and 11 other authors

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

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2017 Wei-Jen Chung, Anneleen Daemen, Jason H. Cheng, Jason E. Long, Jonathan E. Cooper, Bu-Er Wang, Christopher Tran, Mallika Singh

ORCID

, Florian Gnad, Zora Modrusan, Oded Foreman, Melissa R. Junttila

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

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Gisele A. Nishiguchi, Alice Rico, Huw Tanner, Robert J. Aversa

ORCID

, Benjamin R. Taft, Sharadha Subramanian, Lina Setti, Matthew T. Burger, Lifeng Wan, Victoriano Tamez, Aaron Smith, Yan Lou, Paul A. Barsanti, Brent A. Appleton, Mulugeta Mamo and 27 other authors

Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

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2015 Melissa R. Junttila, Weiguang Mao, Xi Wang, Bu-Er Wang, Thinh Pham, John Flygare, Shang-Fan Yu, Sharon Yee, David Goldenberg, Carter Fields, Jeffrey Eastham-Anderson, Mallika Singh

ORCID

, Rajesh Vij, Jo-Anne Hongo, Ron Firestein and 4 other authors

Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer

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Hui Gao, Joshua M. Korn, Stéphane Ferretti, John E. Monahan, Youzhen Wang, Mallika Singh

ORCID

, Chao Zhang, Christian Schnell, Guizhi Yang, Yun Zhang, O. Alejandro Balbin, O. Alejandro Balbin, Stéphanie Barbe, Hongbo Cai, Fergal Casey and 50 other authors

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

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2014 Melissa R. Junttila, Vidusha Devasthali, Jason H. Cheng, Joseph Castillo, Ciara Metcalfe, Anne C. Clermont, Douglas Den Otter, Emily Chan, Hani Bou-Reslan, Tim Cao, William Forrest, Michelle A. Nannini, Dorothy French, Richard Carano, Mark Merchant and 2 other authors

Modeling Targeted Inhibition of MEK and PI3 Kinase in Human Pancreatic Cancer

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Adam S. Adler, Mark L. McCleland, Sharon Yee, Murat Yaylaoglu, Sofia Hussain, Ely Cosino, Gabriel Quinones, Zora Modrusan, Somasekar Seshagiri, Eric Torres, Vivek S. Chopra, Benjamin Haley, Zemin Zhang, Elizabeth M. Blackwood, Mallika Singh

ORCID

and 7 other authors

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

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2012 Mallika Singh

ORCID

, Christopher L. Murriel, Leisa Johnson

Genetically Engineered Mouse Models: Closing the Gap between Preclinical Data and Trial Outcomes

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2010 Mallika Singh

ORCID

, Anthony Lima, Rafael Molina, Patricia Hamilton, Anne C. Clermont, Vidusha Devasthali, Jennifer D. Thompson, Jason H. Cheng, Hani Bou Reslan, Hani Bou Reslan, Calvin C. K. Ho, Timothy C. Cao, Chingwei V. Lee, Michelle A. Nannini, Germaine Fuh and 6 other authors

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

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