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All papers authored by Michael C. Lawrence

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2022 Francois Moreau

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, Nicholas S. Kirk

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, Fa Zhang, Vasily Gelfanov, Edward O. List, Martina Chrudinová, Hari Venugopal

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, Michael C. Lawrence

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, Veronica Jimenez, Fatima Bosch

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, John J. Kopchick

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, Richard D. DiMarchi

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, Emrah Altindis

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, C. Ronald Kahn

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Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

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Nicholas S. Kirk

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, Qi Chen

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, Yingzhe Ginger Wu, Anastasia L. Asante, Haitao Hu

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, Juan F. Espinosa, Francisco Martínez-Olid

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, Mai B. Margetts

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, Faiz A. Mohammed, Vladislav V. Kiselyov

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, David G. Barrett

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, Michael C. Lawrence

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Activation of the human insulin receptor by non-insulin-related peptides

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Yibin Xu, Mai B. Margetts, Hari Venugopal

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, John G. Menting, Nicholas S. Kirk, Tristan I. Croll, Carlie Delaine, Briony E. Forbes, Michael C. Lawrence

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How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor

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Xiaochun Xiong, Alan Blakely

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, Jin Hwan Kim, John G. Menting, Ingmar B. Schäfer

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, Heidi L. Schubert, Rahul Agrawal, Theresia Gutmann

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, Carlie Delaine, Yi Wolf Zhang, Gizem Olay Artik

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, Allanah Merriman, Debbie Eckert, Michael C. Lawrence

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, Ünal Coskun and 5 other authors

Symmetric and asymmetric receptor conformation continuum induced by a new insulin

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2021 Michael C. Lawrence

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Understanding insulin and its receptor from their three-dimensional structures

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Yen-Shan Chen

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, Jeremy Gleaton

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, Balamurugan Dhayalan

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, Nelson B. Phillips

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, Yule Liu

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, Laurie Broadwater

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, Mark A. Jarosinski

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, Deepak Chatterjee

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, Michael C. Lawrence

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, Thomas Hattier

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, M. Dodson Michael, M. Dodson Michael, Dodson M. Michael, Michael Aaron Weiss

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Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone–receptor activation

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2020 Xiaochun Xiong, John G. Menting, Maria M. Disotuar, Nicholas A. Smith, Carlie A. Delaine, Gabrielle Ghabash, Rahul Agrawal, Xiaomin Wang, Xiao He, Simon J. Fisher, Christopher A. MacRaild

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, Raymond S. Norton

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, Joanna Gajewiak, Briony E. Forbes

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, Brian J. Smith

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and 4 other authors

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

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Yibin Xu, Nicholas S. Kirk, Hariprasad Venugopal

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, Mai B. Margetts, Tristan I. Croll, Jarrod J. Sandow, Andrew I. Webb, Carlie A. Delaine, Briony E. Forbes, Michael C. Lawrence

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How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor

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2019 Michael C. Lawrence

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Insulin and its receptor: a grand challenge in structural biology

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2018 Felix Weis

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, John G. Menting, Mai B. Margetts, Shu Jin Chan, Yibin Xu, Norbert Tennagels, Paulus Wohlfart

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, Thomas Langer

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, Christoph W. Müller

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, Matthias K. Dreyer

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, Michael C. Lawrence

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The signalling conformation of the insulin receptor ectodomain

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Michael A. Weiss

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, Michael C. Lawrence

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A thing of beauty: Structure and function of insulin's “aromatic triplet”

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Yibin Xu, Geoffrey K.-W. Kong, John G. Menting, Mai B. Margetts, Carlie A. Delaine, Lauren M. Jenkin, Vladislav V. Kiselyov, Pierre De Meyts, Briony E. Forbes

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, Michael C. Lawrence

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How ligand binds to the type 1 insulin-like growth factor receptor

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2017 Bianca van Lierop, Shee Chee Ong, Alessia Belgi, Carlie Delaine, Sofianos Andrikopoulos, Naomi L. Haworth, John G. Menting, Michael C. Lawrence

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, Andrea J. Robinson, Briony E. Forbes

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Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

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Michael D. Glidden, Khadijah Aldabbagh, Nelson B. Phillips, Kelley Carr, Yen-Shan Chen, Jonathan Whittaker, Manijeh Phillips, Nalinda P. Wickramasinghe, Nischay Rege, Mamuni Swain, Yi Peng, Yanwu Yang, Michael C. Lawrence

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, Vivien C. Yee, Faramarz Ismail-Beigi and 1 other authors

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

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Michael D. Glidden, Yanwu Yang, Nicholas A. Smith, Nelson B. Phillips, Kelley Carr, Nalinda P. Wickramasinghe, Faramarz Ismail-Beigi, Michael C. Lawrence

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, Brian J. Smith, Michael A. Weiss

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

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Antonino Belfiore, Roberta Malaguarnera, Veronica Vella, Michael C. Lawrence

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, Laura Sciacca, Francesco Frasca, Andrea Morrione, Riccardo Vigneri

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

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Michael C. Lawrence

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, Peter M. Colman

Vale Colin Ward—A Leader in Receptor Structural Biology

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Lin Chen, Yibin Xu, Wilson Wong, W. Wang, Jennifer K. Thompson, Julie Healer, Ethan D. Goddard-Borger, Michael C. Lawrence

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, Alan F. Cowman

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Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

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2016 John G. Menting, Joanna Gajewiak, Christopher A. MacRaild

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, Danny Hung-Chieh Chou, Maria M. Disotuar, Nicholas A. Smith, Charleen Miller, Judit Erchegyi, Jean E. Rivier, Baldomero M. Olivera, Briony E. Forbes

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, Brian J. Smith, Raymond S. Norton

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, Helena Safavi-Hemami, Michael C. Lawrence

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A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

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Callum F. Lawrence, Mai B. Margetts, John G. Menting, Nicholas A. Smith, Brian J. Smith, Colin W. Ward, Michael C. Lawrence

ORCID

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

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