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All papers authored by Richard Possemato

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2023 Yuyang Liu

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, Frederick S. Yen

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, Nathalie Ropek

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, Ross A. Weber

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, Mark Gad

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, Hanan Alwaseem

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, Alexandra E. Pagano

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, Søren Heissel

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and 9 other authors

Autoregulatory control of mitochondrial glutathione homeostasis

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Jong Shin

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, Hannan Mir, Maaz A. Khurram, Kenji M. Fujihara, Brian D. Dynlacht, Timothy J. Cardozo, Richard Possemato

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Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle

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2021 Erdem M. Terzi

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, Vladislav O. Sviderskiy

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, Samantha W. Alvarez, Gabrielle C. Whiten

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, Richard Possemato

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Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

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2020 Vladislav O. Sviderskiy

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, Lili Blumenberg, Elizabeth Gorodetsky

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, Triantafyllia R. Karakousi, Nicole Hirsh, Samantha W. Alvarez, Erdem M. Terzi, Efiyenia Kaparos

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, Gabrielle C. Whiten

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, Shakirah Ssebyala, Peter Tonzi, Hannan Mir

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, Benjamin G. Neel, Tony T. Huang, Sylvia Adams and 2 other authors

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε

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Fei Li, Wai-Lung Ng

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, Troy A. Luster

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, Hai Hu, Vladislav O. Sviderskiy, Catríona M. Dowling

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, Kate E. R. Hollinshead, Paula Zouitine, Hua Zhang, Qingyuan Huang, Michela Ranieri

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, Wei Wang, Zhaoyuan Fang, Ting Chen

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, Jiehui Deng and 15 other authors

Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer

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Lin Wu, Kate E. R. Hollinshead, Yuhan Hao, Christy Au, Lina Kroehling, Charles Ng, Woan-Yu Lin, Dayi Li, Hernandez Moura Silva, Jong Shin, Juan J. Lafaille, Richard Possemato

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, Michael E. Pacold, Thales Papagiannakopoulos, Alec C. Kimmelman and 2 other authors

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

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2019 Caroline R. Amendola, James P. Mahaffey, Seth J. Parker, Ian M. Ahearn, Wei-Ching Chen, Mo Zhou, Helen Court, Jie Shi, Sebastian L. Mendoza, Michael J. Morten, Eli Rothenberg, Eyal Gottlieb, Youssef Z. Wadghiri, Richard Possemato

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, Stevan R. Hubbard and 3 other authors

KRAS4A directly regulates hexokinase 1

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Richard Possemato

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Targeting Iron Metabolism in Breast Cancer: Ferroptosis and Genome Stability

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Richard Possemato

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Minding the Ls and Qs

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Vladislav O. Sviderskiy, Erdem M. Terzi, Richard Possemato

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Iron–Sulfur Cluster Metabolism Impacts Iron Homeostasis, Ferroptosis Sensitivity, and Human Disease

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2018 Richard Possemato

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Erratum To: Aspartate is a Limiting Metabolite for Cancer Cell Proliferation Under Hypoxia and in Tumours (nature Cell Biology, (2018), 20, 7, (775-781), 10.1038/s41556-018-0118-z)

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Javier Garcia-Bermudez, Xiphias Ge Zhu, Vladislav O. Sviderskiy, Matija Snuderl, Lou Baudrier, Konnor La, Justine Fidelin, Thales Papagiannakopoulos, Henrik Molina, Caroline A. Lewis

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, Richard L. Possemato

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, Kıvanç Birsoy

ORCID

Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

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Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, Henrik Molina, Matija Snuderl, Caroline A. Lewis

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, Richard L. Possemato

ORCID

, Kıvanç Birsoy

ORCID

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

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Samantha W. Alvarez, Richard Possemato

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Leveraging the iron-starvation response to promote ferroptosis

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Denise R. Minton, Minwoo Nam, Daniel J. McLaughlin, Jong Shin, Erol C. Bayraktar, Samantha W. Alvarez, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, David M. Sabatini, Kıvanç Birsoy, Richard Possemato

ORCID

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

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2017 Samantha W. Alvarez, Vladislav O. Sviderskiy, Erdem M. Terzi, Thales Papagiannakopoulos, Andre L. Moreira, Sylvia Adams, David M. Sabatini, Kıvanç Birsoy, Richard Possemato

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NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

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This paper was not found in any repository; the policy of its publisher is unknown or unclear.

Richard Possemato

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H3 K27m Mutant Gliomas Are Selectively Killed by Onc201, a Small Molecule Inhibitor of Dopamine Receptor D2

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Martin Vaeth, Jun Yang, Stuart E. Turvey, Edgar Serfling, Mate Maus

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, Stefan Klein-Hessling, Elizaveta Freinkman, Miriam Eckstein, Scott Cameron, Friederike Berberich-Siebelt, Richard Possemato

ORCID

, Stefan Feske

Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

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Volkan I. Sayin, Sarah E. LeBoeuf

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, Simranjit X. Singh, Shawn M. Davidson, Douglas Biancur, Betul S. Guzelhan, Samantha W. Alvarez, Warren L. Wu, Triantafyllia R. Karakousi, Anastasia Maria Zavitsanou, Julian Ubriaco, Alexander Muir, Dimitris Karagiannis, Patrick J. Morris, Craig J. Thomas and 3 other authors

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

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2016 Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan, Jason M. Rohde, Caroline A. Lewis, Lotteke J. Y. M. Swier, Richard Possemato

ORCID

, Walter W. Chen, Lucas B. Sullivan, Brian P. Fiske, Steve Cho, Elizaveta Freinkman, Kıvanç Birsoy, Monther-Remaileh Abu, Yoav D. Shaul and 17 other authors

Erratum: Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

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