Doumet Georges Helou

All papers authored by Doumet Georges Helou

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2023 Emily Howard, Benjamin P. Hurrell, Doumet Georges Helou

, Pedram Shafiei-Jahani, Spyridon Hasiakos, Jacob Painter, Sonal Srikanth

, Yousang Gwack

, Omid Akbari

Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models

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Deepak Pokhreal, Bruno Crestani, Doumet Georges Helou

Macrophage Implication in IPF: Updates on Immune, Epigenetic, and Metabolic Pathways

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Christine Quach, Doumet Georges Helou

, Meng Li, Benjamin Pierre Hurrell, Emily Howard, Pedram Shafiei-Jahani, Pejman Soroosh, Jing-Hsiung James Ou, Babak Razani, Virender Rehan, Omid Akbari

Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome

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Doumet Georges Helou

, Christine Quach, Marshall Fung, Jacob D. Painter, Benjamin P. Hurrell, Yong-Hwee Eddie Loh, Emily Howard, Pedram Shafiei-Jahani, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari

Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells

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2022 Benjamin P. Hurrell, Doumet Georges Helou

, Emily Howard, Jacob D. Painter, Pedram Shafiei-Jahani, Arlene H. Sharpe

, Omid Akbari

PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability

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Yumei Li, Jiyoung Lee, Doumet Georges Helou

, Omid Akbari, Jing-Hsiung James Ou

Analysis of the interplay between hepatitis B virus-positive hepatocytes and Kupffer cells ex vivo using mice as a model

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Benjamin P. Hurrell, Doumet Georges Helou

, Pedram Shafiei-Jahani, Emily Howard, Jacob D. Painter, Christine Quach, Omid Akbari

Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity

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Lauriane Galle-Treger, Doumet Georges Helou

, Christine Quach

, Emily Howard, Benjamin P. Hurrell, German R. Aleman Muench, Pedram Shafiei-Jahani, Jacob D. Painter, Andrea Iorga, Lily Dara, Juliet Emamaullee

, Lucy Golden-Mason

, Hugo R. Rosen, Pejman Soroosh, Omid Akbari

Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23

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Doumet Georges Helou

, Pedram Shafiei-Jahani, Benjamin P. Hurrell, Jacob D. Painter, Christine Quach, Emily Howard, Omid Akbari

LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity

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2021 Emily Howard, Benjamin P. Hurrell, Doumet Georges Helou

, Christine Quach, Jacob D. Painter, Pedram Shafiei-Jahani, Marshall Fung, Parkash S. Gill, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma

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Doumet Georges Helou

, Aurélie Mauras

, François Fasquelle, Juliane Sousa Lanza

, Philippe M. Loiseau

, Didier Betbeder, Sandrine Cojean

Intranasal vaccine from whole Leishmania donovani antigens provides protection and induces specific immune response against visceral leishmaniasis

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Brittany Rocque, Arianna Barbetta, Pranay Singh, Cameron Goldbeck, Doumet Georges Helou

, Yong-Hwee Eddie Loh, Nolan Ung, Jerry Lee, Omid Akbari, Juliet Emamaullee

Creation of a Single Cell RNASeq Meta-Atlas to Define Human Liver Immune Homeostasis

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Pedram Shafiei-Jahani, Doumet Georges Helou

, Benjamin P. Hurrell, Emily Howard, Christine Quach

, Jacob D. Painter, Lauriane Galle-Treger, Meng Li, Yong-Hwee Eddie Loh, Omid Akbari

CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

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Pedram Shafiei-Jahani, Doumet Georges Helou

, Benjamin P. Hurrell, Lauriane Galle-Treger, Emily Howard, Christine Quach, Jacob D. Painter, Marshall Fung, Richard Lo, Hooman Allayee, Omid Akbari

CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation

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2020 Benjamin P. Hurrell, Emily Howard, Lauriane Galle-Treger, Doumet Georges Helou

, Pedram Shafiei-Jahani, Jacob D. Painter, Omid Akbari

Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity

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Pedram Shafiei-Jahani, Benjamin P. Hurrell, Lauriane Galle-Treger, Doumet Georges Helou

, Emily Howard, Jacob Painter

, Richard Lo, Gavin Lewis, Pejman Soroosh, Omid Akbari

DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus

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Emily Howard, Gavin Lewis, Lauriane Galle-Treger, Benjamin P. Hurrell, Doumet Georges Helou

, Pedram Shafiei-Jahani, Jacob D. Painter, German Aleman Muench, Pejman Soroosh, Omid Akbari

IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism and ameliorates airway hyperreactivity

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Doumet Georges Helou

, Pedram Shafiei-Jahani, Richard Lo, Emily Howard, Benjamin P. Hurrell, Lauriane Galle-Treger, Jacob D. Painter

, Gavin Lewis, Pejman Soroosh, Arlene H. Sharpe

, Omid Akbari

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

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Vanessa Granger, Friederike Jönsson, Benoît Noël, Doumet Helou

, Sylvie Chollet-Martin, Luc De Chaisemartin

Neutrophil activation by immune complexes in vitro: a model for IgG-mediated anaphylaxis

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Emily Diane Howard, Hadi Maazi, Benjamin P. Hurrell, Lauriane Galle-Treger, Doumet Georges Helou

, Pedram Shafiei Jahani, Jacob Painter, Hooman Allayee, Omid Akbari

Phenotype-driven screening of 150 strains of mice for allergic lung inflammation identified strains representative of heterogeneous human asthma cohorts

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All papers authored by Doumet Georges Helou