Thomas Helleday - Dissemin

Papers authored by Thomas Helleday

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2014 Manuel Luis Orta, Andreas Höglund, José Manuel Calderón-Montaño, Inmaculada Domínguez, Estefanía Burgos-Morón, Torkild Visnes

, Nuria Pastor, Cecilia Ström, Miguel López-Lázaro, Thomas Helleday

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

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Thomas Helleday

, Saeed Eshtad, Serena Nik-Zainal

Mechanisms underlying mutational signatures in human cancers

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Chunxia Gao, Emer Bourke, Martin Scobie, Melina Arcos Famme, Tobias Koolmeister, Thomas Helleday

, Leif A. Eriksson, Noel F. Lowndes, James A. L. Brown

Rational design and validation of a Tip60 histone acetyltransferase inhibitor

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Sophia X. Pfister, Sara Ahrabi, Lykourgos-Panagiotis Zalmas

, Sovan Sarkar, François Aymard, Csanád Z. Bachrati, Thomas Helleday

, Gaëlle Legube, Nicholas B. La Thangue, Andrew C. G. Porter, Timothy C. Humphrey

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

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Emma Bolderson, Eva Petermann, Laura Croft, Amila Suraweera, Raj K. Pandita, Tej K. Pandita, Thomas Helleday

, Kum Khanna, Derek J. Richard

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks

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Thomas Helleday

Cancer Phenotypic Lethality, exemplified by the non-essential MTH1 enzyme being required for cancer survival.

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Kv Huber, Eidarus Salah, Branka Radic, Manuela Gridling, Jm Elkins, Alexey Stukalov, As Jemth, Camilla Gokturk, Camilla Göktürk, Kumar Sanjiv, Kia Strömberg, Therese Pham, Uw Berglund, Jacques Colinge

, Kl Bennett and 4 other authors

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

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Helge Gad, Tobias Koolmeister, Ann-Sofie Jemth, Saeed Eshtad, Sylvain A. Jacques, Cecilia E. Strom, Linda M. Svensson, Niklas Schultz, Thomas Lundbäck, Berglind Osk Einarsdottir, Aljona Saleh, Camilla Göktürk, Pawel Baranczewski, Richard Svensson, Ronnie P.-A. Berntsson and 42 other authors

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

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Sabin Llona-Minguez, Andreas Höglund, Sylvain A. Jacques, Tobias Koolmeister, Thomas Helleday

Chemical strategies for development of ATR inhibitors

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2013 Evgenia Gubanova, Natalia Issaeva, Camilla Gokturk, Tatjana Djureinovic, Thomas Helleday

SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways

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Lorenzo Costantino, Sotirios K. Sotiriou, Juha K. Rantala, Simon Magin, Emil Mladenov, Thomas Helleday

, James E. Haber, George Iliakis, Olli P. Kallioniemi, Thanos D. Halazonetis

Break-induced replication repair of damaged forks induces genomic duplications in human cells

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Thomas Helleday

PrimPol breaks replication barriers

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Thomas Helleday

Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice:

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F. Kopper, Frederik Köpper, Cathrin Bierwirth, Margarete Schön, Meike Kunze, Ingegerd Elvers, Dominique Kranz, Priyanka Saini, Manoj B. Menon, David Walter, Claus Storgaard Sørensen, Matthias Gaestel, Thomas Helleday

, Michael P. Schön, Matthias Dobbelstein

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

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Lykourgos-Panagiotis Zalmas

, Amanda S. Coutts, Thomas Helleday

, Nicholas B. La Thangue

E2F-7 couples DNA damage-dependent transcription with the DNA repair process

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Matthieu Desroses, Marie‐Caroline Jacques‐Cordonnier, Sabin Llona‐Minguez, Sylvain Jacques, Tobias Koolmeister, Thomas Helleday

, Martin Scobie

A Convenient Microwave‐Assisted Propylphosphonic Anhydride (T3P^®) Mediated One‐Pot Pyrazolone Synthesis

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Matthieu Desroses, Tobias Koolmeister, Sylvain Jacques, Sabin Llona-Minguez, Marie-Caroline Jacques-Cordonnier, Armando Cázares-Körner, Thomas Helleday

, Martin Scobie

A facile and efficient synthesis of tetrahydro-β-carbolines

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Navita Somaiah, John Yarnold, Anne Lagerqvist, Kai Rothkamm, Thomas Helleday

Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy

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Manuel Luís Orta, José Manuel Calderón-Montaño, Inmaculada Domínguez, Nuria Pastor, Estefanía Burgos-Morón, Miguel López-Lázaro, Felipe Cortés, Santiago Mateos, Thomas Helleday

5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

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Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder, Petra Groth, Marie-Christine Weller, Nadeem Shaikh, Enric Domingo, Nnennaya Kanu, Sally M. Dewhurst, Eva Gronroos

, Su Kit Chew, Andrew J. Rowan, Arne Schenk, Michal Sheffer

, Michael Howell and 6 other authors

Replication stress links structural and numerical cancer chromosomal instability

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Papers authored by Thomas Helleday