Matthias R. Bauer

All papers authored by Matthias R. Bauer

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2023 Benjamin C. Whitehurst

, Matthias R. Bauer

, Fredrik Edfeldt, Anders Gunnarsson, Christian Margreitter

, Philip B. Rawlins, R. Ian Storer

Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery

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2020 Matthias R. Bauer

, Andreas Krämer, Giovanni Settanni

, Rhiannon N. Jones, Xiaomin Ni, Raysa Khan Tareque, Alan R. Fersht, John Spencer

, Andreas C. Joerger

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

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2019 Matthias R. Bauer

, Rhiannon N. Jones, Raysa K. Tareque, Bradley Springett, Felix A. Dingler, Lorena Verduci, Ketan J. Patel, Alan R. Fersht, Andreas C. Joerger

, John Spencer

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

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Sara Gomes

, Bartolomeo Bosco, Joana B. Loureiro, Helena Ramos

, Liliana Raimundo

, Joana Soares, Nair Nazareth, Valentina Barcherini

, Lucília Domingues

, Carla Oliveira

, Alessandra Bisio

, Silvano Piazza

, Matthias R. Bauer

, João P. Brás

, Maria Inês Almeida

and 6 other authors

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

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Matthias R. Bauer

, Mark D. Mackey

Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein–Ligand Complexes

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2018 Christopher C. T. Sng

, Sorcha O'Byrne, Daniil M. Prigozhin

, Matthias R. Bauer

, Jennifer C. Harvey, Michelle Ruhle, Ben G. Challis, Sara Lear, Lee D. Roberts, Sarita Workman, Tobias Janowitz

, Lukasz Magiera, Rainer Doffinger, Matthew S. Buckland

, Duncan J. Jodrell and 4 other authors

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway

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Matthias G. J. Baud

, Matthias R. Bauer

, Lorena Verduci, Felix A. Dingler, Ketan J. Patel, Deeptee Horil Roy, Andreas C. Joerger, Alan R. Fersht

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

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Naoise C. Synnott, Matthias R. Bauer

, Stephen Madden, Alyson Murray, Rut Klinger, Norma O'Donovan, Darran O'Connor

, William M. Gallagher, John Crown, Alan R. Fersht, Michael J. Duffy

Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007

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Esha Madan, Taylor M. Parker, Matthias R. Bauer

, Alisha Dhiman

, Christopher J. Pelham, Masaki Nagane, M. Lakshmi Kuppusamy, Matti Holmes, Thomas R. Holmes, Kranti Shaik, Kevin Shee, Salome Kiparoidze, Sean D. Smith

, Yu-Soon A. Park, Jennifer J. Gomm and 9 other authors

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53

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2016 Matthias R. Bauer

, Andreas C. Joerger, Alan R. Fersht

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

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Dennis Bromley, Matthias R. Bauer

, Alan R. Fersht, Valerie Daggett

Anin silicoalgorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein

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Matthias R. Bauer

, Rhiannon N. Jones, Rainer Wilcken, Matthias G. J. Baud

, Frank M. Boeckler, Alan R. Fersht, Andreas C. Joerger, John Spencer

Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

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2015 Andreas C. Joerger, Matthias R. Bauer

, Rainer Wilcken, Hannes Harbrecht, Thomas E. Exner, Frank M. Boeckler, John Spencer, Alan R. Fersht, Frank Böckler, Matthias Gj J. Baud

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53

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Tamer M. Ibrahim, Matthias R. Bauer

, Alexander Dörr, Erdem Veyisoglu, Frank M. Boeckler

pROC-Chemotype Plots Enhance the Interpretability of Benchmarking Results in Structure-Based Virtual Screening

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Rainer Wilcken, Markus O. Zimmermann, Matthias R. Bauer

, Trevor J. Rutherford, Alan R. Fersht, Andreas C. Joerger, Frank M. Boeckler

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

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Tamer M. Ibrahim, Matthias R. Bauer

, Frank M. Boeckler

Applying DEKOIS 2.0 in structure-based virtual screening to probe the impact of preparation procedures and score normalization

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2014 Tamer M. Ibrahim, Matthias R. Bauer

, Frank M. Boeckler

Probing the impact of protein and ligand preparation procedures on chemotype enrichment in structure-based virtual screening using DEKOIS 2.0 benchmark sets

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Frank M. Boeckler, Matthias R. Bauer

, Tamer M. Ibrahim, Simon M. Vogel

Use of DEKOIS 2.0 to gain insights for virtual screening

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This paper was not found in any repository; the policy of its publisher is unknown or unclear.

Fm Boeckler, R. Wilcken, Mr Bauer

, Mb Cieslik, Tj Rutherford, Ar Fersht, Ac Joerger

Ligand Binding Assays

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Matthias Rupp

, Matthias R. Bauer

, Rainer Wilcken, Andreas Lange, Michael Reutlinger, Frank M. Boeckler, Frank M. Böckler, Gisbert Schneider

Machine Learning Estimates of Natural Product Conformational Energies

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All papers authored by Matthias R. Bauer