Barrie Kellam
0000-0003-0030-9908
University of Nottingham
78 papers found
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Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization
Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor
Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles
Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1 Receptor in Living Cells
Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2
Synthesis and Matched Molecular Pair Analysis of Covalent Reversible Inhibitors of the Cysteine Protease CPB
Using esterase selectivity to determine the in vivo duration of systemic availability and abolish systemic side-effects of topical β-blockers.
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I
Monitoring ligand-induced changes in receptor conformation with NanoBiT conjugated nanobodies
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor
Structure–Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor
Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery
Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925
A Thieno[2,3-d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor
Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation
Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells
Fluorescently Labeled Morphine Derivatives for Bioimaging Studies
Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors
Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease
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