Peter John Scammells

Papers authored by Peter John Scammells

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2018 Natalie B. Vinh, Nyssa Drinkwater, Tess R. Malcolm, Michael Kassiou

, Leonardo Lucantoni, Peter M. Grin, Georgina S. Butler, Sandra Duffy, Christopher M. Overall

, Vicky M. Avery, Peter J. Scammells

, Sheena McGowan

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases

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Divya Muthiah, Georgia K. Henshaw, Aaron J. DeBono, Ben Capuano, Peter J. Scammells

, Richard Callaghan

Overcoming P-Glycoprotein–Mediated Drug Resistance with Noscapine Derivatives

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Hywel D. Williams

, Leigh Ford, Sifei Han, Kristian J. Tangso, Shea Lim, David M. Shackleford

, David T. Vodak, Hassan Benameur, Colin W. Pouton

, Peter J. Scammells

, Christopher J. H. Porter

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

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Shane M. Devine

, Cassandra Yong, Dzifa Amenuvegbe, Luigi Aurelio, Divya Muthiah, Colin Pouton

, Richard Callaghan, Ben Capuano

, Peter J. Scammells

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

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Jon Kyle Awalt, Peter J. Scammells

, Robert D. Singer

Liquid Assisted Grinding for the N-Demethylation of Alkaloids

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Anitha Kopinathan, Christopher Draper-Joyce

, Monika Szabo, Arthur Christopoulos, Peter J. Scammells

, J. Robert Lane, Ben Capuano

Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-((trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D2 Receptor

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Emma T. van der Westhuizen, Arthur Spathis, Elham Khajehali, Manuela Jörg, Shailesh N. Mistry, Ben Capuano, Andrew B. Tobin, Patrick M. Sexton, Peter J. Scammells

, Celine Valant

, Arthur Christopoulos

Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors

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Tim J. Fyfe, Barbara Zarzycka, Herman D. Lim, Barrie Kellam

, Shailesh N. Mistry

, Vsevolod Katrich

, Peter J. Scammells

, J. Robert Lane, J. Robert Lane, Ben Capuano

A Thieno[2,3-d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

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Juliana C. C. Dallagnol, Elham Khajehali, Emma T. van der Westhuizen, Manuela Jörg, Celine Valant

, Alan G. Gonçalves, Ben Capuano, Arthur Christopoulos, Peter J. Scammells

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

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Luigi Aurelio, Jo-Anne Baltos, Leigh Ford, Anh T. N. Nguyen

, Manuela Jörg, Shane M. Devine

, Celine Valant

, Paul J. White, Arthur Christopoulos, Lauren T. May

, Peter J. Scammells

A Structure–Activity Relationship Study of Bitopic N6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

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Christopher J. Draper-Joyce

, Mayako Michino, Ravi Kumar Verma, Carmen Klein Herenbrink, Jeremy Shonberg, Anitha Kopinathan, Peter J. Scammells

, Ben Capuano, David M. Thal

, Jonathan A. Javitch, Arthur Christopoulos, Lei Shi, J. Robert Lane

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D 2 receptor

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Christopher J. Draper-Joyce

, Ravi Kumar Verma, Mayako Michino, Jeremy Shonberg, Anitha Kopinathan, Carmen Klein Herenbrink, Peter J. Scammells

, Ben Capuano, Ara M. Abramyan, David M. Thal

, Jonathan A. Javitch, Arthur Christopoulos, Lei Shi, J. Robert Lane

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

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Raymond Lam, Arisbel B. Gondin, Meritxell Canals, Barrie Kellam

, Stephen J. Briddon, Bim Graham, Peter J. Scammells

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

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Hywel D. Williams, Leigh Ford, Shea Lim, Sifei Han, John Baumann, Hannah Sullivan, David Vodak, Annabel Igonin, Hassan Benameur, Colin W. Pouton, Peter J. Scammells

, Christopher J. H. Porter

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations

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2017 Yasemin Sahbaz, Tri-Hung Nguyen

, Leigh Ford, Claire L. McEvoy, Hywel D. Williams, Peter J. Scammells

, Christopher J. H. Porter

Ionic Liquid Forms of Weakly Acidic Drugs in Oral Lipid Formulations: Preparation, Characterization, in Vitro Digestion, and in Vivo Absorption Studies

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Karina Pombo-García, Carmen L. Rühl, Raymond Lam, José A. Barreto, Ching-Seng Ang, Peter J. Scammells

, Peter Comba, Leone Spiccia†, Bim Graham, Tanmaya Joshi, Holger Stephan

Zwitterionic Modification of Ultrasmall Iron Oxide Nanoparticles for Reduced Protein Corona Formation

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Alisa Glukhova

, David M. Thal

, Anh T. Nguyen

, Elizabeth A. Vecchio, Manuela Jörg, Peter J. Scammells

, Lauren T. May

, Patrick M. Sexton, Arthur Christopoulos

Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

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Jon Kyle Awalt, Raymond Lam

, Barrie Kellam

, Bim Graham, Peter J. Scammells

, Robert D. Singer

Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

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2016 Manuela Jörg, Alisa Glukhova

, Alaa Abdul-Ridha, Elizabeth A. Vecchio, Anh T. N. Nguyen

, Patrick M. Sexton, Paul J. White, Lauren T. May

, Arthur Christopoulos, Peter J. Scammells

Novel Irreversible Agonists Acting at the A1 Adenosine Receptor

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Elizabeth A. Vecchio, Chung Hui Chuo, Jo-Anne Baltos, Leigh Ford, Peter J. Scammells

, Bing H. Wang, Arthur Christopoulos, Paul J. White, Lauren T. May

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling

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Papers authored by Peter John Scammells