Lari Lehtiö - Dissemin

Papers authored by Lari Lehtiö

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2016 Harikanth Venkannagari, Patricia Verheugd, Jarkko Koivunen

, Teemu Haikarainen, Ezeogo Obaji, Yashwanth Ashok, Mohit Narwal, Taina Pihlajaniemi, Bernhard Lüscher, Lari Lehtiö

Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage

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Amit Nathubhai, Pauline J. Wood, Teemu Haikarainen, Penelope C. Hayward, Silvia Muñoz-Descalzo, Andrew S. Thompson, Matthew D. Lloyd, Lari Lehtiö

, Michael D. Threadgill

Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases

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This paper is made freely available by the publisher.

Teemu Haikarainen, Lari Lehtiö

Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain

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Mariana Schlesinger, Silvia Fernández Villamil, Salomé Vilchez Larrea, Salomé C. Vilchez Larrea, Teemu Haikarainen, Mohit Narwal, Harikanth Venkannagari, Mirtha M. Flawiá, Lari Lehtiö

, Silvia H. Fernández Villamil

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei

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Teemu Haikarainen, Jo Waaler, Alexander Ignatev, Yves Nkizinkiko, Harikanth Venkannagari, Ezeogo Obaji, Stefan Krauss

, Lari Lehtiö

Development and structural analysis of adenosine site binding tankyrase inhibitors

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2015 Helen A. Paine, Amit Nathubhai, Esther C. Y. Woon, Peter T. Sunderland, Pauline J. Wood, Mary F. Mahon, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Mohit Narwal, Lari Lehtiö

, Michael D. Threadgill

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

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Yves Nkizinkiko, B. V. S. Suneel Kumar, Variam Ullas Jeankumar, Teemu Haikarainen, Jarkko Koivunen

, Chanduri Madhuri, Perumal Yogeeswari, Harikanth Venkannagari, Ezeogo Obaji, Taina Pihlajaniemi, Dharmarajan Sriram, Lari Lehtiö

Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics

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Katerina Kumpan, Amit Nathubhai, Chenlu Zhang

, Pauline J. Wood, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Lari Lehtiö

, Michael D. Threadgill

Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases

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2014 Teemu Haikarainen, Stefan Krauss, Lari Lehtiö

Tankyrases: Structure, Function and Therapeutic Implications in Cancer

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Crystall M. D. Swarbrick, Noelia Roman, Nathan Cowieson, Edward I. Patterson, Jeffrey Nanson, Marina I. Siponen, Helena Berglund, Lari Lehtiö

, Jade K. Forwood

Structural Basis for Regulation of the Human Acetyl-CoA Thioesterase 12 and Interactions with the Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Domain

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2013 Teemu Haikarainen, Mohit Narwal, Päivi Joensuu, Lari Lehtiö

Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors

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Teemu Haikarainen, Jarkko Koivunen

, Mohit Narwal, Harikanth Venkannagari, Ezeogo Obaji, Päivi Joensuu, Taina Pihlajaniemi, Lari Lehtiö

para -Substituted 2-Phenyl-3,4-dihydroquinazolin-4-ones As Potent and Selective Tankyrase Inhibitors

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Mohit Narwal, Jarkko Koivunen

, Teemu Haikarainen, Ezeogo Obaji, Ongey E. Legala, Harikanth Venkannagari, Päivi Joensuu, Taina Pihlajaniemi, Lari Lehtiö

Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity

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Martin Welin, Lari Lehtio

, Andreas Johansson, Susanne Flodin, Tomas Nyman, Lionel Tresaugues, Martin Hammarstrom, Susanne Graslund, Pär Nordlund

Substrate Specificity and Oligomerization of Human GMP Synthetase

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Teemu Haikarainen, Harikanth Venkannagari, Mohit Narwal, Ezeogo Obaji, Hao-Wei Lee, Yves Nkizinkiko, Lari Lehtiö

Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4

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Lari Lehtiö

, Nai-Wen Chi, Stefan Krauss

Tankyrases as Drug Targets.

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Mohit Narwal, Teemu Haikarainen, Adyary Fallarero

, Pia M. Vuorela, Lari Lehtiö

Screening and Structural Analysis of Flavones Inhibiting Tankyrases

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Harikanth Venkannagari, Adyary Fallarero

, Karla L. H. Feijs, Bernhard Lüscher, Lari Lehtiö

Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors

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2012 Salomé C. Vilchez Larrea, Teemu Haikarainen, Mohit Narwal, Mariana Schlesinger, Harikanth Venkannagari, Mirtha M. Flawiá, Silvia H. Fernández Villamil, Silvia H. Fernández Villamil, Lari Lehtiö

Inhibition of poly(ADP-ribose) Polymerase Interferes with Trypanosoma cruzi Infection and Proliferation of the Parasite

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Mohit Narwal, Adyary Fallarero

, Pia Vuorela, Lari Lehtiö

Homogeneous Screening Assay for Human Tankyrase

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Papers authored by Lari Lehtiö