L. Miguel Martins

All papers authored by L. Miguel Martins

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2023 Rebeka Popovic

, Yizhou Yu

, Nuno Santos Leal

, Giorgio Fedele

, Samantha H. Y. Loh

, L. Miguel Martins

Upregulation of Tribbles decreases body weight and increases sleep duration

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2022 Giorgio Fedele

, Samantha H. Y. Loh, Ivana Celardo, Nuno Santos Leal

, Susann Lehmann, Ana C. Costa, L. Miguel Martins

Suppression of intestinal dysfunction in a Drosophila model of Parkinson’s disease is neuroprotective

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2021 Yizhou Yu, Giorgio Fedele

, Ivana Celardo, Samantha H. Y. Loh, L. Miguel Martins

Correction: Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease

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Yizhou Yu, Giorgio Fedele

, Ivana Celardo, Samantha H. Y. Loh, L. Miguel Martins

Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease

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2019 Callum P. Rakhit, Ricky M. Trigg, John Le Quesne

, Michael Kelly, Jacqueline A. Shaw

, Catrin Pritchard

, L. Miguel Martins

Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA

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2017 Susann Lehmann, Samantha H. Y. Loh, L. Miguel Martins

Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease.

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2016 S. Lehmann, A. C. Costa, I. Celardo, S. H. Y. Loh, L. Miguel Martins

Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease

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I. Celardo, Costa Ac, A. C. Costa, S. Lehmann, C. Jones, N. Wood

, Mencacci Ne, N. E. Mencacci

, Mallucci Gr, G. R. Mallucci

, S. H. Y. Loh, Loh Sh, Martins Lm, L. Miguel Martins

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease.

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2014 Nicoleta Moisoi, Valentina Fedele, Jennifer Edwards, L. Miguel Martins

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress☆

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Roberta Tufi, Inês P. de Castro, Sonia Gandhi, de Castro Ip, I. P. De Castro, Susann Lehmann, Angelova Pr, Plamena R. Angelova, David Dinsdale, Anne E. Willis, Emma Deas, Hélène Plun-Favreau, Pierluigi Nicotera, Abramov Ay, Andrey Y. Abramov and 7 other authors

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

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2013 I. P. de Castro, A. C. Costa, I. Celardo, R. Tufi, D. Dinsdale, S. H. Y. Loh, L. M. Martins

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants

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Costa Ac, A. C. Costa, S. H. Y. Loh, L. Miguel Martins

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease

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L. Miguel Martins

HtrA2 Peptidase

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2012 H. Plun-Favreau, Vs S. Burchell, Km M. Holmström, Z. Yao, E. Deas, K. Cain, V. Fedele, Nicoleta Moisoi, M. Campanella, L. Miguel Martins

, Nw W. Wood

, Av V. Gourine, Ay Y. Abramov

HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion

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2011 Ellen Gerhardt, Simone Gräber, Éva M. Szegő, Nicoleta Moisoi, L. Miguel Martins

, Tiago F. Outeiro, Pawel Kermer

Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice

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Jc C. Fitzgerald, M. D. Camprubi, Laura Dunn, Hc-C. Wu, Ny Y. Ip, Rejko Kruger, Lm M. Martins

, Nw W. Wood

, Helene Plun-Favreau

Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function

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2010 Emma Deas, Helene Plun-Favreau, Sonia Gandhi, Howard Desmond, Svend Kjaer, Samantha H. Y. Loh, Alan E. M. Renton, Robert J. Harvey, Alexander J. Whitworth, Lm Miguel Martins

, Andrey Y. Abramov, Nicholas W. Wood

PINK1 cleavage at position A103 by the mitochondrial protease PARL

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Nicole Kieper, Kira M. Holmström, Dalila Ciceri, Fabienne C. Fiesel, Hartwig Wolburg, Elena Ziviani

, Alexander J. Whitworth, Luisa Miguel Martins

, Philipp J. Kahle, Rejko Krüger

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

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2009 Luke S. Tain, Ruhena B. Chowdhury, Ran N. Tao, Helene Plun-Favreau, Nicoleta Moisoi, L. Miguel Martins

, Julian Downward, Alexander J. Whitworth, Nicolas Tapon

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

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2008 N. Moisoi, K. Klupsch, V. Fedele, P. East, S. Sharma, A. Renton, H. Plun Favreau, R. E. Edwards, P. Teismann, M. D. Esposti, A. D. Morrison, N. W. Wood

, J. Downward, L. M. Martins

, Klupsch K Fedele V East P Sharma S Renton A Plun-Favreau H Edwards RE Teismann P Esposti MD Morrison AD Wood NW Downward J Martins L.-M. Moisoi N.

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response.

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All papers authored by L. Miguel Martins