All papers authored by Ruben van Boxtel
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Flavia Peci,
Markus J. van Roosmalen,
Diego Montiel González,
Eline J. M. Bertrums,
Inge van der Werf,
Lucca L. M. Derks,
Niels M. Groenen,
Mark Verheul,
Laurianne Trabut,
Cayetano Pleguezuelos-Manzano,
Arianne M. Brandsma,
Evangelia Antoniou,
Dirk Reinhardt
and 3 other authors
Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox
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Jip van Dinter,
Ruben van Boxtel
Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells
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Joris Demmers ,
Wilbert P. Vermeij ,
Marjolein Baar,
Serena Bruens,
Aristea Magaraki,
Ewart Kuijk ,
Myrthe Jager ,
Sarra Merzouk,
Renata M. C. Brandt ,
Janneke Kouwenberg ,
Ruben van Boxtel ,
Edwin Cuppen ,
Joris Pothof ,
Jan H. J. Hoeijmakers
Different responses to DNA damage determine ageing differences between organs
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Joske Ubels ,
Mark Verheul,
Markus J. van Roosmalen,
Niels M. Groenen,
Rurika Oka ,
Ewart Kuijk ,
Susana M. Chuva de Sousa Lopes,
Susana M. Chuva de Sousa Lopes,
Ruben van Boxtel ,
Ruben van Boxtel
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Myrthe Jager ,
Ruby Lieshout ,
Petra E. de Ruiter,
Mauro D. Locati,
Nicolle Besselink ,
Bastiaan van der Roest ,
Roel Janssen ,
Sander Boymans ,
Jeroen de Jonge,
Jan N. M. IJzermans ,
Michail Doukas ,
Monique M. A. Verstegen,
Ruben van Boxtel ,
Luc J. W. van der Laan
and 2 other authors
Precancerous liver diseases do not cause increased mutagenesis in liver stem cells
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Rurika Oka ,
Anne Hakkert,
Linda Schild,
Marli E. Ebus ,
Michael R. van Gerven ,
Danny A. Zwijnenburg ,
Piet Molenaar,
Lieke L. Hoyng,
M. Emmy M. Dolman,
Anke H. W. Essing,
Bianca Koopmans,
Thomas Helleday ,
Jarno Drost ,
Ruben van Boxtel
and 3 other authors
Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma
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Alex Cagan ,
Tim H. H. Coorens ,
Matthew D. C. Neville ,
Rashesh Sanghvi ,
Mathijs A. Sanders,
Thomas R. W. Oliver ,
Daniel Leongamornlert ,
Peter Ellis,
Ayesha Noorani,
Thomas J. Mitchell ,
Timothy M. Butler ,
Yvette Hooks,
Anne Y. Warren,
Mette Jorgensen
and 15 other authors
The mutational landscape of human somatic and germline cells
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Eline J. M. Bertrums,
Markus J. van Roosmalen,
Damon A. Hofman,
Rurika Oka,
Mark Verheul,
Freek Manders ,
Joske Ubels,
Mirjam E. Belderbos ,
Ruben van Boxtel
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Melissa K. Dennis,
Paulo J. C. Lin,
Rurika Oka ,
Dominik Witzigmann ,
Lukas Villiger ,
Weihong Qi,
Martina Hruzova,
Lucas Kissling ,
Daniela Lenggenhager,
Costanza Borrelli,
Sabina Egli,
Nina Frey,
Noëlle Bakker,
John A. Walker
and 17 other authors
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
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Tanja Rothgangl,
Dominik Witzigmann ,
Rurika Oka ,
Paulo J. C. Lin,
Weihong Qi,
Sharan Janjuha,
Christian Berk ,
Femke Ringnalda,
Mitchell B. Beattie,
Markus Stoffel,
Beat Thöny,
Jonathan Hall,
Hubert Rehrauer ,
Ruben van Boxtel
and 2 other authors
In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA
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Indi P. Joore,
Rurika Oka ,
Michal Mokry ,
Anke H. M. van Vugt,
Ruben van Boxtel ,
Monique M. A. Verstegen,
Peter M. van Hasselt,
Edward E. S. Nieuwenhuis,
Sabine A. Fuchs
Prime editing for functional repair in patient-derived disease models
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Myrthe Jager ,
Bastiaan van der Roest ,
Mauro D. Locati,
Arne Van Hoeck ,
Jerome Korzelius ,
Roel Janssen ,
Nicolle Besselink ,
Sander Boymans ,
Ruben van Boxtel ,
Edwin Cuppen
Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells
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Myrthe Jager ,
Bastiaan van der Roest ,
Mauro D. Locati,
Arne Van Hoeck ,
Jerome Korzelius ,
Roel Janssen ,
Nicolle Besselink ,
Sander Boymans ,
Ruben van Boxtel ,
Edwin Cuppen
The mutational impact of culturing human pluripotent and adult stem cells
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Thanasis Margaritis,
Tito Candelli,
Luka Mathijsen,
Carola Ammerlaan,
Ravian L. van Ineveld,
Sepide Derakhshan,
Sanne de Haan,
Emmy Dolman,
Philip Lijnzaad,
Lars Custers,
Harry Begthel,
Hindrik H. D. Kerstens
and 16 other authors
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity
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CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank
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Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli
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Ruben van Boxtel ,
Michal Mokry ,
Edward E. S. Nieuwenhuis,
Menno P. Creyghton,
Marije Bartels,
Paul J. Coffer
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