Galina Lepesheva - Dissemin

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All papers authored by Galina Lepesheva

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2021 Beatrice Mercorelli, Marta Celegato, Anna Luganini

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, Giorgio Gribaudo

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, Galina I. Lepesheva

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, Arianna Loregian

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The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs

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2020 David C. Lamb, Tatiana Y. Hargrove, Bin Zhao, Zdzislaw Wawrzak, Jared V. Goldstone, WilliamDavid David Nes, Steven L. Kelly, Michael R. Waterman, John J. Stegeman, Galina I. Lepesheva

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Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

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Tatiana Y. Hargrove, Zdzislaw Wawrzak, F. Peter Guengerich

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, Galina I. Lepesheva

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A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis

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2019 Laura Friggeri, Tatiana Y. Hargrove, Zdzislaw Wawrzak, F. Peter Guengerich

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, Galina I. Lepesheva

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Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

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Francisca Hildemagna Guedes-Da-Silva, Denise da Gama Jaén Batista, Cristiane França Da Silva, Beatriz Philot Pavão, Marcos Meuser Batista, Otacílio Cruz Moreira, Letícia Rocha Quintino Souza, Constança Britto, Girish Rachakonda, Fernando Villalta, Galina I. Lepesheva

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, Maria de Nazaré Correia Soeiro

Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi

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2018 Laura Friggeri, Tatiana Y. Hargrove, Girish Rachakonda, Anna L. Blobaum, Paxtyn Fisher, Gabriel Melo de Oliveira, Cristiane França da Silva, Maria de Nazaré C. Soeiro, W. David Nes, Craig W. Lindsley

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, Fernando Villalta, F. Peter Guengerich

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, Galina I. Lepesheva

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Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae

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Tatiana Y. Hargrove, Zdzislaw Wawrzak, Paxtyn M. Fisher, Stella A. Child

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, W. David Nes, F. Peter Guengerich

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, Michael R. Waterman, Galina I. Lepesheva

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Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

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This paper was not found in any repository; the policy of its publisher is unknown or unclear.

Laura Friggeri, Tatiana Y. Hargrove, Zdzislaw Wawrzak, Anna L. Blobaum, Girish Rachakonda, Craig W. Lindsley

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, Fernando Villalta, W. David Nes, Maurizio Botta, F. Peter Guengerich

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, Galina I. Lepesheva

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Sterol 14α-Demethylase Structure-Based Design of VNI ((R)-N-(1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis

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