Ian Copple - Dissemin

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All papers authored by Ian Copple

This paper is made freely available by the publisher.

2021 Benjamin K. Y. Chan

ORCID

, Mohamed Elmasry, Shiva S. Forootan, Giusy Russomanno

ORCID

, Tobias M. Bunday, Fang Zhang, Nathalie Brillant, Philip J. Starkey Lewis

ORCID

, Rhona Aird, Emanuele Ricci, Timothy D. Andrews, Rowena L. Sison‐Young, Amy L. Schofield, Yongxiang Fang, Adam Lister and 9 other authors

Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration

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This paper is made freely available by the publisher.

Ian M. Copple

ORCID

, B. Kevin Park, Christopher E. Goldring

Gene signatures reduce the stress of preclinical drug hepatotoxicity screening

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2019 Jonathan P. Evans, Boleslaw K. Winiarski, Paul A. Sutton, Robert P. Jones, Lorenzo Ressel, Carrie A. Duckworth, D. Mark Pritchard, Zhi-Xiu Lin, Vicky L. Fretwell, Elizabeth M. Tweedle, Eithne Costello, Christopher E. Goldring, Ian M. Copple

ORCID

, B. Kevin Park, Daniel H. Palmer and 1 other authors

Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

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2018 Jonathan P. Evans, Boleslaw K. Winiarski, Paul A. Sutton, Robert P. Jones, Lorenzo Ressel, Carrie A. Duckworth, Mark D. Pritchard, D. Mark Pritchard, Zhi-Xiu Lin, Vicky L. Fretwell, Fretwell L. Vicky, Elizabeth M. Tweedle, Eithne Costello, Christopher E. Goldring, Ian M. Copple

ORCID

and 4 other authors

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

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Adam Lister, Soline Bourgeois, Pedro H. Imenez Silva

ORCID

, Isabel Rubio-Aliaga, Philippe Marbet, Joanne Walsh, Luke M. Shelton, Bettina Keller, Francois Verrey, Olivier Devuyst, Pieter Giesbertz

ORCID

, Hannelore Daniel, Christopher E. Goldring, Ian M. Copple

ORCID

, Carsten A. Wagner

ORCID

and 1 other authors

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis

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2017 Shiva S. Forootan, Fiona E. Mutter, Anja Kipar, Takao Iwawaki, Ben Francis

ORCID

, Christopher E. Goldring, B. Kevin Park, Ian M. Copple

ORCID

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

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This paper was not found in any repository, but could be made available legally by the author.

L. Oni, Db Hawcutt, Ma Turner, Mw Beresford, S. McWilliam, C. Barton, Bk Park, P. Murray, B. Wilm

ORCID

, I. Copple

ORCID

, R. Floyd, M. Peak, A. Sharma, Dj Antoine

Optimising the use of medicines to reduce acute kidney injury in children and babies

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Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock

ORCID

, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi and 33 other authors

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

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This paper was not found in any repository, but could be made available legally by the author.

Monday O. Ogese, Lee Faulkner, Roz E. Jenkins, Neil S. French, Ian M. Copple

ORCID

, Daniel J. Antoine, Mohamed Elmasry, Hasan Malik, Christopher E. Goldring, Brian Kevin Park, Catherine J. Betts, Dean J. Naisbitt

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells

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Joanna I. Clarke

ORCID

, Shiva Seyed Forootan, Jonathan D. Lea, Lawrence S. Howell, Josep Monne Rodriguez

ORCID

, Anja Kipar, Christopher E. Goldring, B. Kevin Park, Ian M. Copple

ORCID

, Daniel J. Antoine

Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies

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This paper was not found in any repository, but could be made available legally by the author.

2016 Jessica L. Clarke, James B. Murray, B. Kevin Park, Ian M. Copple

ORCID

Roles of Nrf2 in drug and chemical toxicity

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Michael H. L. Wong, Holly K. Bryan, Ian M. Copple

ORCID

, Rosalind E. Jenkins, Pak Him Chiu, Jaclyn Bibby, Neil G. Berry, Neil R. Kitteringham, Christopher E. Goldring, Paul M. O’Neill, B. Kevin Park

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites

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2015 Luke M. Shelton, Adam Lister, Joanne Walsh, Rosalind E. Jenkins, Michael H. L. Wong, Cliff Rowe, Emanuele Ricci, Lorenzo Ressel, Yongxiang Fang, Philippe Demougin, Vanja Vukojevic, Paul M. O'Neill, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park and 3 other authors

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

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Fiona E. Mutter, B. Kevin Park, Ian M. Copple

ORCID

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress

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Adedamola Olayanju, Ian M. Copple

ORCID

, Holly K. Bryan, George T. Edge, Rowena L. Sison, Min Wei Wong, Zheng-Quan Lai, Zhi-Xiu Lin, Karen Dunn, Christopher M. Sanderson, Ahmad F. Alghanem, Michael J. Cross, Ewa C. Ellis, Magnus Ingelman-Sundberg, Hassan Z. Malik and 4 other authors

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

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2014 Ian M. Copple

ORCID

, Luke M. Shelton, Joanne Walsh, Denise V. Kratschmar, Adam Lister, Alex Odermatt, Christopher E. Goldring, Albena T. Dinkova-Kostova, Tadashi Honda, B. Kevin Park, B. Kevin Park

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

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Joanne Walsh, Rosalind E. Jenkins, Michael Wong, Adedamola Olayanju, Helen Powell, Paul M. O'Neill, Ian Copple

ORCID

, Paul M. O’Neill, Christopher E. P. Goldring, Neil R. Kitteringham, B. Kevin Park, B. Kevin Park

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

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2013 Tao Wright, Sarah L. Rea, Alice Goode, Andrew J. Bennett, Thomas Ratajczak, Jed E. Long, Mark S. Searle, Christopher E. Goldring, Ian M. Copple

ORCID

, B. Kevin Park, Robert Layfield

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone

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This paper was not found in any repository, but could be made available legally by the author.

Luke M. Shelton, B. Kevin Park, Ian M. Copple

ORCID

, Kevin Park

Role of Nrf2 in protection against acute kidney injury

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2012 Amy E. Mercer, B. Van De Water, Ian M. Copple

ORCID

, James Firman, Gail Donegan, Bram Herpers, Michael Hl L. Wong, J. Chadwick, James Chadwick, Andreia D. Bringela, Maria Ls S. Cristiano

ORCID

, Bob van de Water, Stephen A. Ward, Amy Chadwick, Paul M. O’Neill and 2 other authors

Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials

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