Sophie Bertrand
0000-0002-7159-1157
GlaxoSmithKline
11 papers found
Refreshing results…
Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic heterocycles
One-Pot Suzuki-Hydrogenolysis Protocol for the Modular Synthesis of 2,5-Diaryltetrazoles
Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target
Modular Access to Eight‐Membered N‐Heterocycles by Directed Carbonylative C−C Bond Activation of Aminocyclopropanes
Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads With Varying Binding Modes Identified by Fragment Screening
Identification of Vps34 as a key-off target activity in the search for a suitable PI3K delta oral inhibitor for the treatment of respiratory diseases and its potential impact on toxicity
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits
Structure-guided optimization of small molecule c-Abl activators
Direct small-molecule kinase activation: Novel approaches for a new era of drug discovery.
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