Luc Brunsveld
www.tue.nl
0000-0001-5675-511X
TU Eindhoven
165 papers found
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Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry
Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt
Dynamic Protease Activation on a Multimeric Synthetic Protein Scaffold via Adaptable DNA‐Based Recruitment Domains
Therapy Monitoring of EGFR-Positive Non–Small-Cell Lung Cancer Patients Using ddPCR Multiplex Assays
Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site
Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand
Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt
Assembly of dynamic supramolecular polymers on a DNA origami platform
Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators
Fluorescence Anisotropy-Based Tethering for Discovery of Protein–Protein Interaction Stabilizers
Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering
Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
Correction of the NSE concentration in hemolyzed serum samples improves its diagnostic accuracy in small-cell lung cancer
Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products
Fragment-based Differential Targeting of PPI Stabilizer Interfaces
Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt
Designed Asymmetric Protein Assembly on a Symmetric Scaffold
Conjugated Protein Domains as Engineered Scaffold Proteins
Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs
Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation
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