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All papers authored by Robert Helsley

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2024 Evelyn A. Bates

ORCID

, Zachary A. Kipp

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, Wang-Hsin Lee

ORCID

, Genesee J. Martinez

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, Lauren Weaver, Kathryn N. Becker, Sally N. Pauss, Justin F. Creeden

ORCID

, Garrett B. Anspach

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, Robert N. Helsley

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, Mei Xu

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, Maria E. C. Bruno, Marlene E. Starr

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, Terry D. Hinds

ORCID

FOXS1 is increased in liver fibrosis and regulates TGFβ responsiveness and proliferation pathways in human hepatic stellate cells

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2023 Tyler W. Benson, Kelsey A. Conrad, Xinmin S. Li

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ORCID

, Robert N. Helsley

ORCID

, Rebecca C. Schugar, Taylor M. Coughlin

ORCID

, Caris Wadding-Lee

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, Salma Fleifil

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, Hannah M. Russell, Timothy Stone

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, Michael Brooks, Jennifer A. Buffa, Kevin Mani, Martin Björck

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and 12 other authors

Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms

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2021 Michelle S. M. A. Damen

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, Traci E. Stankiewicz, Se-Hyung Park, Robert N. Helsley

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, Calvin C. Chan

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, Maria E. Moreno-Fernandez, Jessica R. Doll

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ORCID

, De’Broski R. Herbert, Samir Softic, Senad Divanovic

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Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae

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2020 Rebecca C. Schugar

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, Christy M. Gliniak

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, Lucas J. Osborn

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, William Massey

ORCID

, Naseer Sangwan, Anthony Horak, Rakhee Banerjee, Robert N. Helsley

ORCID

, Danny Orabi, Amanda L. Brown, Amy Burrows, Chelsea Finney, Kevin K. Fung, Frederick M. Allen, Daniel Ferguson and 20 other authors

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

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Preeti Pathak, Robert N. Helsley

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, Amanda L. Brown, Jennifer A. Buffa, Ibrahim Choucair, Ina Nemet, Camelia Baleanu Gogonea, Camelia Baleanu Gogonea, Valentin Gogonea, Zeneng Wang, Jose Carlos Garcia-Garcia, Lei Cai

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, Ryan E. Temel, Naseer Sangwan, Stanley L. Hazen and 1 other authors

Small Molecule Inhibition of Gut Microbial Choline Trimethylamine Lyase Activity Alters Host Cholesterol and Bile Acid Metabolism.

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Robert N. Helsley

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, Samir Softic

Fructose metabolism by the guts cuts liver fat

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Sarah R. Anthony

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, Adrienne Guarnieri, Lindsey Lanzillotta

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, Anamarie Gozdiff, Lisa C. Green, Katherine O’Grady, Robert N. Helsley

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, A. Phillip Owens Iii, Michael Tranter

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HuR expression in adipose tissue mediates energy expenditure and acute thermogenesis independent of UCP1 expression

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2019 Amanda L. Brown, Kelsey Conrad, Daniela S. Allende, Anthony D. Gromovsky, Renliang Zhang, Chase K. Neumann, A. Phillip Owens, Michael Tranter, Robert N. Helsley

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Dietary Choline Supplementation Attenuates High-Fat-Diet–Induced Hepatocellular Carcinoma in Mice

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Robert N. Helsley

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, Venkateshwari Varadharajan, Amanda L. Brown, Anthony D. Gromovsky, Rebecca C. Schugar, Iyappan Ramachandiran, Kevin Fung, Mohammad Nasser Kabbany, Rakhee Banerjee, Chase K. Neumann, Chelsea Finney, Preeti Pathak, Danny Orabi, Lucas J. Osborn, William Massey

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and 18 other authors

Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

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Taesik Gwag, Zhaojie Meng, Yipeng Sui, Robert N. Helsley

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, Se-Hyung Park, Shuxia Wang, Richard N. Greenberg, Changcheng Zhou

ORCID

Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis

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2018 Anthony D. Gromovsky, Rebecca C. Schugar, Amanda L. Brown, Robert N. Helsley

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, Amy C. Burrows, Daniel Ferguson, Renliang Zhang, Brian E. Sansbury, Richard G. Lee, Richard E. Morton, Daniela S. Allende, John S. Parks, Matthew Spite, J. Mark Brown

Δ-5 Fatty Acid DesaturaseFADS1Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators

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2017 Robert N. Helsley

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, Changcheng Zhou

ORCID

Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view

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Rebecca C. Schugar, Diana M. Shih, Manya Warrier, Amy Burrows, Robert N. Helsley

ORCID

, Daniel Ferguson, Amanda L. Brown, Anthony D. Gromovsky, Markus Heine, Arunachal Chatterjee, Lin Li, Xinmin S. Li, Zeneng Wang, Belinda Willard, YongHong Meng and 23 other authors

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

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2016 Daniel Ferguson, Jun Zhang, Matthew A. Davis, Robert N. Helsley

ORCID

, Lise-Lotte Vedin, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Daniela S. Allende, Paolo Parini, J. Mark Brown

The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis

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Robert N. Helsley

ORCID

, Yipeng Sui, Se-Hyung Park, Zun Liu, Richard G. Lee, Beibei Zhu, Philip A. Kern, Changcheng Zhou

ORCID

Targeting IκB kinase β in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions

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Se-Hyung Park, Zun Liu, Yipeng Sui, Robert N. Helsley

ORCID

, Beibei Zhu, David K. Powell, Philip A. Kern, Changcheng Zhou

ORCID

IKKβ is essential for adipocyte survival and adaptive adipose remodeling in obesity

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2015 Yipeng Sui, Robert N. Helsley

ORCID

, Se-Hyung Park, Xiulong Song, Zun Liu, Changcheng Zhou

ORCID

Intestinal Pregnane X Receptor Links Xenobiotic Exposure and Hypercholesterolemia

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2014 Yipeng Sui, Se-Hyung Park, Jinxian Xu, Sébastien Monette, Robert N. Helsley

ORCID

, Seong-Su Han, Changcheng Zhou

ORCID

IKKβ links vascular inflammation to obesity and atherosclerosis

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Yipeng Sui, Se‐Hyung-H. Park, Robert N. Helsley

ORCID

, Manjula Sunkara, Frank J. Gonzalez, Andrew J. Morris, Changcheng Zhou

ORCID

Bisphenol A Increases Atherosclerosis in Pregnane X Receptor‐Humanized ApoE Deficient Mice

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2013 Robert Nathaniel Helsley

ORCID

, Yipeng Sui, Ni Ai, Se-Hyung Park, William J. Welsh, Changcheng Zhou

Pregnane X Receptor Mediates Dyslipidemia Induced by the HIV Protease Inhibitor Amprenavir in Mice

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