Anne Filppula - Dissemin

All papers authored by Anne Filppula

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2019 Helinä Kahma

, Anne M. Filppula

, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen

, Eric A. Evangelista, Rheem A. Totah

, Janne T. Backman

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

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2016 U. Warpman Berglund, U. Warpman Berglund

, K. Sanjiv, H. Gad, C. Kalderen, T. Koolmeister, T. Pham, C. Gokturk, R. Jafari, G. Maddalo, B. Seashore-Ludlow, A. Chernobrovkin, A. Manoilov, I. S. Pateras, A. Rasti and 33 other authors

Validation and development of MTH1 inhibitors for treatment of cancer

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2015 Janne T. Backman, Anne M. Filppula

, Mikko Niemi, Pertti J. Neuvonen

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

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Troels K. Bergmann

, Anne M. Filppula

, Terhi Launiainen, Flemming Nielsen, Janne T. Backman, Kim Brosen

Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60-year-old Caucasian woman with ovarian carcinoma

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2014 A. Tornio, A. M. Filppula

, O. Kailari, M. Neuvonen, T. H. Nyrönen, T. Tapaninen, P. J. Neuvonen, M. Niemi, J. T. Backman

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions

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Anne M. Filppula

, Pertti J. Neuvonen, Janne T. Backman

In Vitro Assessment of Time-Dependent Inhibitory Effects on CYP2C8 and CYP3A Activity by Fourteen Protein Kinase Inhibitors

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2013 A. M. Filppula

, A. Tornio, M. Niemi, P. J. Neuvonen, J. T. Backman

Gemfibrozil Impairs Imatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

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2012 Anne M. Filppula

, Mikko Neuvonen, Jouko Laitila, Pertti J. Neuvonen, Janne T. Backman

Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response

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Am M. Filppula

, J. Laitila, Pj J. Neuvonen, Jt T. Backman

Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates

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2011 Anne M. Filppula

, Jouko Laitila, Pertti J. Neuvonen, Janne T. Backman

Reevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant Concentrations

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A. M. Filppula

, J. Laitila, P. J. Neuvonen, J. T. Backman

Contribution of Cyp2c8 and Cyp3a4 to the Main Metabolic Pathway of Imatinib in Vitro

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2010 T. Karonen, A. Filppula

, J. Laitila, M. Niemi, P. J. Neuvonen, J. T. Backman

Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast

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All papers authored by Anne Filppula