Michael McLeish - Dissemin

All papers authored by Michael McLeish

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2019 Ferran Planas

, Michael J. McLeish

Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis

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2017 Katharina Pallitsch

, Megan P. Rogers, Forest H. Andrews, Friedrich Hammerschmidt

, Michael J. McLeish

Phosphonodifluoropyruvate is a mechanism-based inhibitor of phosphonopyruvate decarboxylase from Bacteroides fragilis

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S. A. Adediran, Pan-Fen Wang, Abbas G. Shilabin

, Charles A. Baron, Michael J. McLeish

, R. F. Pratt

Specificity and mechanism of mandelamide hydrolase catalysis

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Megan P. D. Zahniser, Shreenath Prasad, Malea M. Kneen, Cheryl A. Kreinbring, Gregory A. Petsko, Dagmar Ringe, Michael J. McLeish

Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily

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2016 Forest H. Andrews, Cindy Wechsler, Megan P. Rogers, Danilo Meyer, Kai Tittmann, Michael J. McLeish

Mechanistic and Structural Insight to an Evolved Benzoylformate Decarboxylase with Enhanced Pyruvate Decarboxylase Activity

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2014 Sabrina Loschonsky, Tobias Wacker, Simon Waltzer, Pier Paolo Giovannini, Michael J. McLeish

, Susana L. A. Andrade, Michael Müller

Extended Reaction Scope of Thiamine Diphosphate Dependent Cyclohexane-1,2-dione Hydrolase: From CC Bond Cleavage to CC Bond Ligation

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Forest Hoyt Andrews, Megan Patricia Rogers, Lake N. Paul, Michael John McLeish

Perturbation of the Monomer-Monomer Interfaces of the Benzoylformate Decarboxylase Tetramer

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Hetalben Patel, Natalia S. Nemeria, Forest Hoyt Andrews, Michael John McLeish

, Frank Jordan

Identification of Charge Transfer Transitions Related to Thiamin-Bound Intermediates on Enzymes Provides a Plethora of Signatures Useful in Mechanistic Studies

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2013 Qian Wu, Michael J. McLeish

Kinetic and pH Studies on Human Phenylethanolamine N-Methyltransferase

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Forest H. Andrews, Michael J. McLeish

Using site-saturation mutagenesis to explore mechanism and substrate specificity in thiamin diphosphate-dependent enzymes

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Forest H. Andrews, Alan R. Tom, Peter R. Gunderman, Walter R. P. Novak, Michael John McLeish

A Bulky Hydrophobic Residue Is Not Required To Maintain the V-Conformation of Enzyme-Bound Thiamin Diphosphate

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2011 Forest H. Andrews, Michael J. McLeish

Substrate specificity in thiamin diphosphate-dependent decarboxylases

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Malea M. Kneen, Razvan Stan, Alejandra Yep, Ryan P. Tyler, Choedchai Saehuan, Michael J. McLeish

Characterization of a thiamin diphosphate-dependent phenylpyruvate decarboxylase from Saccharomyces cerevisiae

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2010 R. F. Pratt, Michael J. McLeish

Structural Relationship between the Active Sites of β-Lactam-Recognizing and Amidase Signature Enzymes: Convergent Evolution?

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Gabriel S. Brandt, Malea M. Kneen, Gregory A. Petsko, Dagmar Ringe, Michael J. McLeish

Active-Site Engineering of Benzaldehyde Lyase Shows That a Point Mutation Can Confer Both New Reactivity and Susceptibility to Mechanism-Based Inhibition

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Nyssa Drinkwater, Hoan The Vu, Kimberly M. Lovell, Kevin R. Criscione, Brett M. Collins, Thomas E. Prisinzano, Sally-Ann Poulsen, Sally‑Ann Pulsen, Michael J. McLeish

, Gary L. Grunewald, Jennifer L. Martin

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors

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2009 Alejandra Yep, Michael J. McLeish

Engineering the Substrate Binding Site of Benzoylformate Decarboxylase

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Polina Georgieva, Qian Wu, Michael J. McLeish

, Fahmi Himo

The Reaction Mechanism of Phenylethanolamine N-Methyltransferase: A Density Functional Theory Study

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Gabriel S. Brandt, Malea M. Kneen, Sumit Chakraborty, Ahmet T. Baykal

, Natalia Nemeria, Alejandra Yep, David I. Ruby, Gregory A. Petsko, George L. Kenyon, Michael J. McLeish

, Frank Jordan, Dagmar Ringe

Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor

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Sumit Chakraborty, Natalia S. Nemeria, Anand Balakrishnan, Gabriel S. Brandt, Malea M. Kneen, Alejandra Yep, Michael J. McLeish

, George L. Kenyon, Gregory A. Petsko, Dagmar Ringe, Frank Jordan

Detection and Time Course of Formation of Major Thiamin Diphosphate-Bound Covalent Intermediates Derived from a Chromophoric Substrate Analogue on Benzoylformate Decarboxylase†

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All papers authored by Michael McLeish