All papers authored by Christian Frezza
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2024
Joycelyn Tan 
,
Sam Virtue ,
Dougall M. Norris,
Olivia J. Conway,
Ming Yang,
Guillaume Bidault,
Christopher Gribben,
Fatima Lugtu ,
Ioannis Kamzolas ,
James R. Krycer ,
Richard J. Mills,
Lu Liang,
Conceição Pereira ,
Martin Dale,
Amber S. Shun-Shion
and 15 other authors
,
Sam Virtue ,
Dougall M. Norris,
Olivia J. Conway,
Ming Yang,
Guillaume Bidault,
Christopher Gribben,
Fatima Lugtu ,
Ioannis Kamzolas ,
James R. Krycer ,
Richard J. Mills,
Lu Liang,
Conceição Pereira ,
Martin Dale,
Amber S. Shun-Shion
and 15 other authors
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells
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2023
Lorea Valcarcel-Jimenez ,
Christian Frezza
,
Christian Frezza
Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism
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Connor Rogerson ,
Marco Sciacovelli ,
Lucas A. Maddalena,
Andromachi Pouikli,
Marc Segarra-Mondejar,
Lorea Valcarcel-Jimenez ,
Christina Schmidt,
Ming Yang,
Elena Ivanova,
Joshua Kent,
Ariane Mora,
Danya Cheeseman,
Jason S. Carroll,
Gavin Kelsey,
Christian Frezza
,
Marco Sciacovelli ,
Lucas A. Maddalena,
Andromachi Pouikli,
Marc Segarra-Mondejar,
Lorea Valcarcel-Jimenez ,
Christina Schmidt,
Ming Yang,
Elena Ivanova,
Joshua Kent,
Ariane Mora,
Danya Cheeseman,
Jason S. Carroll,
Gavin Kelsey,
Christian Frezza
FOXA2 controls the anti-oxidant response in FH-deficient cells
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Alex von Kriegsheim,
Alexander Hooftman ,
Christian G. Peace ,
Dylan G. Ryan ,
Emily A. Day ,
Ming Yang,
Anne F. McGettrick ,
Maureen Yin ,
Montano En,
Erica N. Montano,
Lihong Huo,
Toller Kawahisa Je,
Juliana E. Toller-Kawahisa,
Vincent Zecchini,
Tristram A. J. Ryan
and 18 other authors
,
Christian G. Peace ,
Dylan G. Ryan ,
Emily A. Day ,
Ming Yang,
Anne F. McGettrick ,
Maureen Yin ,
Montano En,
Erica N. Montano,
Lihong Huo,
Toller Kawahisa Je,
Juliana E. Toller-Kawahisa,
Vincent Zecchini,
Tristram A. J. Ryan
and 18 other authors
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
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2022
Marco Sciacovelli,
Aurelien Dugourd,
Lorea Valcarcel Jimenez ,
Ming Yang,
Efterpi Nikitopoulou,
Ana S. H. Costa ,
Laura Tronci,
Veronica Caraffini,
Paulo Rodrigues,
Christina Schmidt,
Dylan Gerard Ryan ,
Timothy Young,
Vincent R. Zecchini,
Sabrina H. Rossi ,
Charlie Massie
and 13 other authors
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,
Ming Yang,
Efterpi Nikitopoulou,
Ana S. H. Costa ,
Laura Tronci,
Veronica Caraffini,
Paulo Rodrigues,
Christina Schmidt,
Dylan Gerard Ryan ,
Timothy Young,
Vincent R. Zecchini,
Sabrina H. Rossi ,
Charlie Massie
and 13 other authors
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Lorea Valcarcel-Jimenez ,
Connor Rogerson ,
Cissy Yong ,
Christina Schmidt ,
Ming Yang ,
Monica Cremades-Rodelgo ,
Victoria Harle ,
Victoria Offord ,
Kim Wong ,
Ariane Mora ,
Alyson Speed ,
Veronica Caraffini ,
Maxine Gia Binh Tran ,
Eamonn R. Maher,
Grant D. Stewart
and 3 other authors
,
Connor Rogerson ,
Cissy Yong ,
Christina Schmidt ,
Ming Yang ,
Monica Cremades-Rodelgo ,
Victoria Harle ,
Victoria Offord ,
Kim Wong ,
Ariane Mora ,
Alyson Speed ,
Veronica Caraffini ,
Maxine Gia Binh Tran ,
Eamonn R. Maher,
Grant D. Stewart
and 3 other authors
HIRA loss transforms FH -deficient cells
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Angela Riedel,
Moutaz Helal ,
Luisa Pedro ,
Jonathan J. Swietlik,
David Shorthouse,
Werner Schmitz ,
Lisa Haas,
Timothy Young ,
Ana S. H. da Costa,
Sarah Davidson,
Pranjali Bhandare,
Elmar Wolf ,
Benjamin A. Hall,
Christian Frezza ,
Thordur Oskarsson
and 1 other authors
,
Luisa Pedro ,
Jonathan J. Swietlik,
David Shorthouse,
Werner Schmitz ,
Lisa Haas,
Timothy Young ,
Ana S. H. da Costa,
Sarah Davidson,
Pranjali Bhandare,
Elmar Wolf ,
Benjamin A. Hall,
Christian Frezza ,
Thordur Oskarsson
and 1 other authors
Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma
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2021
Dylan Gerard Ryan ,
Ming Yang,
Hiran A. Prag ,
Giovanny Rodriguez Blanco,
Efterpi Nikitopoulou,
Marc Segarra-Mondejar,
Christopher A. Powell ,
Tim Young ,
Nils Burger,
Jan Lj J. Miljkovic,
Michal Minczuk,
Michael P. Murphy ,
Alex von Kriegsheim,
Christian Frezza
,
Ming Yang,
Hiran A. Prag ,
Giovanny Rodriguez Blanco,
Efterpi Nikitopoulou,
Marc Segarra-Mondejar,
Christopher A. Powell ,
Tim Young ,
Nils Burger,
Jan Lj J. Miljkovic,
Michal Minczuk,
Michael P. Murphy ,
Alex von Kriegsheim,
Christian Frezza
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
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John S. O’Neill ,
Nathaniel P. Hoyle ,
J. Brian Robertson,
Rachel S. Edgar,
Andrew D. Beale ,
Sew Y. Peak-Chew ,
Jason Day,
Ana S. H. Costa ,
Christian Frezza ,
Helen C. Causton
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,
Nathaniel P. Hoyle ,
J. Brian Robertson,
Rachel S. Edgar,
Andrew D. Beale ,
Sew Y. Peak-Chew ,
Jason Day,
Ana S. H. Costa ,
Christian Frezza ,
Helen C. Causton
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Stanley W. K. Ng,
Foad J. Rouhani,
Simon F. Brunner ,
Natalia Brzozowska,
Sarah J. Aitken ,
Ming Yang,
Federico Abascal ,
Luiza Moore ,
Efterpi Nikitopoulou,
Lia Chappell,
Daniel Leongamornlert ,
Aleksandra Ivovic,
Philip Robinson ,
Timothy Butler ,
Mathijs A. Sanders
and 16 other authors
,
Natalia Brzozowska,
Sarah J. Aitken ,
Ming Yang,
Federico Abascal ,
Luiza Moore ,
Efterpi Nikitopoulou,
Lia Chappell,
Daniel Leongamornlert ,
Aleksandra Ivovic,
Philip Robinson ,
Timothy Butler ,
Mathijs A. Sanders
and 16 other authors
Convergent somatic mutations in metabolism genes in chronic liver disease
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Clément Bodineau ,
Mercedes Tomé,
Sarah Courtois ,
Ana S. H. Costa ,
Marco Sciacovelli ,
Benoit Rousseau,
Elodie Richard,
Pierre Vacher ,
Carlos Parejo-Pérez,
Emilie Bessede,
Christine Varon,
Pierre Soubeyran,
Christian Frezza ,
Piedad del Socorro Murdoch,
Victor H. Villar
and 1 other authors
,
Mercedes Tomé,
Sarah Courtois ,
Ana S. H. Costa ,
Marco Sciacovelli ,
Benoit Rousseau,
Elodie Richard,
Pierre Vacher ,
Carlos Parejo-Pérez,
Emilie Bessede,
Christine Varon,
Pierre Soubeyran,
Christian Frezza ,
Piedad del Socorro Murdoch,
Victor H. Villar
and 1 other authors
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
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Jorge Andrade ,
Chenyue Shi,
Ana S. H. Costa ,
Jeongwoon Choi,
Jaeryung Kim ,
Anuradha Doddaballapur ,
Toshiya Sugino ,
Yu Ting Ong ,
Marco Castro ,
Barbara Zimmermann,
Manuel Kaulich ,
Stefan Guenther,
Kerstin Wilhelm,
Yoshiaki Kubota ,
Thomas Braun
and 4 other authors
,
Chenyue Shi,
Ana S. H. Costa ,
Jeongwoon Choi,
Jaeryung Kim ,
Anuradha Doddaballapur ,
Toshiya Sugino ,
Yu Ting Ong ,
Marco Castro ,
Barbara Zimmermann,
Manuel Kaulich ,
Stefan Guenther,
Kerstin Wilhelm,
Yoshiaki Kubota ,
Thomas Braun
and 4 other authors
Control of endothelial quiescence by FOXO-regulated metabolites
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Vitor Vieira,
Abel Sousa,
Christoph Kuppe ,
Marco Sciacovelli ,
Enio Gjerga ,
Attila Gabor,
Kristina B. Emdal,
Aurelien Dugourd ,
Jennifer Kranz,
Miguel Rocha,
Jesper V. Olsen ,
Julio Saez‐Rodriguez ,
Christian Frezza ,
Eric M. J. Bindels,
Dorte B. Bekker‐Jensen
and 3 other authors
,
Marco Sciacovelli ,
Enio Gjerga ,
Attila Gabor,
Kristina B. Emdal,
Aurelien Dugourd ,
Jennifer Kranz,
Miguel Rocha,
Jesper V. Olsen ,
Julio Saez‐Rodriguez ,
Christian Frezza ,
Eric M. J. Bindels,
Dorte B. Bekker‐Jensen
and 3 other authors
Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses
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2020
Patrizia Romani ,
Lorea Valcarcel-Jimenez ,
Christian Frezza ,
Sirio Dupont
,
Lorea Valcarcel-Jimenez ,
Christian Frezza ,
Sirio Dupont
Crosstalk between mechanotransduction and metabolism
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John S. O’ Neill,
John S. O’Neill ,
Nathaniel P. Hoyle ,
J. Brian Robertson,
Rachel S. Edgar,
Andrew D. Beale ,
Sew Y. Peak-Chew ,
Jason Day,
Ana S. H. Costa ,
Christian Frezza ,
Helen C. Causton
Download from www.nature.com
,
Nathaniel P. Hoyle ,
J. Brian Robertson,
Rachel S. Edgar,
Andrew D. Beale ,
Sew Y. Peak-Chew ,
Jason Day,
Ana S. H. Costa ,
Christian Frezza ,
Helen C. Causton
Download from www.nature.com
Peter S. J. Bailey ,
Brian M. Ortmann,
Anthony W. Martinelli ,
Jack W. Houghton ,
Ana S. H. Costa ,
Stephen P. Burr,
Robin Antrobus,
Christian Frezza ,
James A. Nathan
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,
Brian M. Ortmann,
Anthony W. Martinelli ,
Jack W. Houghton ,
Ana S. H. Costa ,
Stephen P. Burr,
Robin Antrobus,
Christian Frezza ,
James A. Nathan
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Hiran A. Prag ,
Anja V. Gruszczyk ,
Margaret M. Huang ,
Timothy E. Beach,
Timothy Young ,
Laura Tronci,
Efterpi Nikitopoulou,
John F. Mulvey ,
Raimondo Ascione ,
Anna Hadjihambi ,
Michael J. Shattock,
Luc Pellerin,
Kourosh Saeb-Parsy ,
Christian Frezza ,
Andrew M. James
and 3 other authors
,
Anja V. Gruszczyk ,
Margaret M. Huang ,
Timothy E. Beach,
Timothy Young ,
Laura Tronci,
Efterpi Nikitopoulou,
John F. Mulvey ,
Raimondo Ascione ,
Anna Hadjihambi ,
Michael J. Shattock,
Luc Pellerin,
Kourosh Saeb-Parsy ,
Christian Frezza ,
Andrew M. James
and 3 other authors
Mechanism of succinate efflux upon reperfusion of the ischaemic heart
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Fevzi Demircioglu,
Jun Wang ,
Juliana Candido,
Ana S. H. Costa ,
Pedro Casado ,
Beatriz de Luxan Delgado,
Louise E. Reynolds ,
Jesus Gomez-Escudero,
Emma Newport,
Vinothini Rajeeve,
Ann-Marie Baker ,
Marina Roy-Luzarraga,
Trevor A. Graham ,
Julie Foster,
Yu Wang
and 10 other authors
,
Juliana Candido,
Ana S. H. Costa ,
Pedro Casado ,
Beatriz de Luxan Delgado,
Louise E. Reynolds ,
Jesus Gomez-Escudero,
Emma Newport,
Vinothini Rajeeve,
Ann-Marie Baker ,
Marina Roy-Luzarraga,
Trevor A. Graham ,
Julie Foster,
Yu Wang
and 10 other authors
Cancer associated fibroblast FAK regulates malignant cell metabolism
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2019
Jack L. Martin,
Ana S. H. Costa ,
Anja V. Gruszczyk,
Timothy E. Beach,
Fay M. Allen,
Hiran A. Prag ,
Elizabeth C. Hinchy,
Krishnaa Mahbubani ,
Mazin Hamed,
Laura Tronci,
Efterpi Nikitopoulou,
Andrew M. James,
Thomas Krieg,
Alan J. Robinson,
Margaret M. Huang
and 7 other authors
,
Anja V. Gruszczyk,
Timothy E. Beach,
Fay M. Allen,
Hiran A. Prag ,
Elizabeth C. Hinchy,
Krishnaa Mahbubani ,
Mazin Hamed,
Laura Tronci,
Efterpi Nikitopoulou,
Andrew M. James,
Thomas Krieg,
Alan J. Robinson,
Margaret M. Huang
and 7 other authors
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation
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