Liang Ouyang
www.mendeley.com
0000-0001-5537-8834
19 papers found
Refreshing results…
Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors
Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFRL858R/T790M/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers
Novel Medicinal Chemistry Strategies Targeting CDK5 for Drug Discovery
Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer
Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X-ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site
Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson’s Disease
Unraveling the Design and Discovery of c-Jun N-Terminal Kinase Inhibitors and Their Therapeutic Potential in Human Diseases
Small Molecules Targeting Activated Cdc42-Associated Kinase 1 (ACK1/TNK2) for the Treatment of Cancers
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer
Discovery, Synthesis, and Evaluation of Highly Selective Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) Inhibitor for the Potential Treatment of Metastatic Triple-Negative Breast Cancer
Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy
Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery
Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions
Developing potent LC3-targeting AUTAC tools for protein degradation with selective autophagy
Promising inhibitors targeting Mpro: an ideal strategy for anti-SARS-CoV-2 drug discovery
Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types
Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: Bioactivities, structure-activity relationships and preliminary molecular mechanisms
The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy
Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research
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