Kelly Chibale - Dissemin

All papers authored by Kelly Chibale

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2021 Claire Le Manach, Jean Dam, John G. Woodland, Gurminder Kaur, Lutete P. Khonde, Christel Brunschwig, Mathew Njoroge

, Kathryn J. Wicht, André Horatscheck, Tanya Paquet, Grant A. Boyle, Liezl Gibhard, Dale Taylor, Nina Lawrence, Tomas Yeo and 31 other authors

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

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André Horatscheck, Ana Andrijevic, Aloysius T. Nchinda, Claire Le Manach

, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge

, Janette Reader, Mariëtte van der Watt and 12 other authors

Correction to “Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model”

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2020 André Horatscheck, Ana Andrijevic, Aloysius T. Nchinda, Claire Le Manach

, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge

, Janette Reader, Mariëtte van der Watt and 12 other authors

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

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Jessica N. Akester, Paul Njaria, Aloysius Nchinda, Claire Le Manach, Alissa Myrick, Vinayak Singh

, Nina Lawrence, Mathew Njoroge

, Dale Taylor, Atica Moosa, Anthony J. Smith, Elizabeth J. Brooks, Anne J. Lenaerts, Gregory T. Robertson, Thomas R. Ioerger and 2 other authors

Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity

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2019 Mathew Njoroge

, Gurminder Kaur, Marlene Espinoza-Moraga, Antonina Wasuna, Godwin Akpeko Dziwornu, Ronnett Seldon, Dale Taylor, John Okombo, Digby F. Warner, Kelly Chibale

Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture

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John Okombo, Christel Brunschwig, Kawaljit Singh, Godwin Akpeko Dziwornu, Linley Barnard, Mathew Njoroge

, Sergio Wittlin, Kelly Chibale

Antimalarial Pyrido[1,2-a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies

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2018 Godfrey Mayoka, Mathew Njoroge

, John Okombo, Liezl Gibhard, Margarida Sanches-Vaz, Diana Fontinha, Lyn-Marie Birkholtz, Janette Reader, Mariëtte van der Watt, Theresa L. Coetzer, Sonja Lauterbach, Alisje Churchyard, Belinda Bezuidenhout, Timothy J. Egan

, Clive Yeates and 3 other authors

Structure–Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2-a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria

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Claire Le Manach, Tanya Paquet, Kathryn Wicht, Aloysius T. Nchinda, Christel Brunschwig, Mathew Njoroge

, Liezl Gibhard, Dale Taylor, Nina Lawrence, Sergio Wittlin, Charles J. Eyermann, Gregory S. Basarab, James Duffy, Paul V. Fish

, Leslie J. Street and 1 other authors

Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose–Response Curves against Multidrug Resistant Parasite Strains

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Nishanth Kandepedu, Diego Gonzàlez Cabrera, Srinivas Eedubilli, Dale Taylor, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge

, Nina Lawrence, Tanya Paquet, Charles J. Eyermann, Thomas Spangenberg

, Gregory S. Basarab, Leslie J. Street, Kelly Chibale

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

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Aloysius T. Nchinda, Claire Le Manach, Tanya Paquet, Diego Gonzàlez Cabrera, Kathryn J. Wicht, Christel Brunschwig, Mathew Njoroge

, Efrem Abay, Dale Taylor, Nina Lawrence, Sergio Wittlin, María-Belén Jiménez-Díaz, María Santos Martínez, Santiago Ferrer, Iñigo Angulo-Barturen and 5 other authors

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγnull Mouse Model of Malaria

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2017 Colin R. Wilson, Richard K. Gessner, Atica Moosa, Ronnett Seldon, Digby F. Warner, Valerie Mizrahi

, Candice Soares de Melo, Sandile B. Simelane, Aloysius Nchinda, Efrem Abay, Dale Taylor, Mathew Njoroge

, Christel Brunschwig, Nina Lawrence, Helena I. M. Boshoff and 22 other authors

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies

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John Okombo, Kawaljit Singh, Godfrey Mayoka, Ferdinand Ndubi, Linley Barnard, Peter M. Njogu, Mathew Njoroge

, Liezl Gibhard, Christel Brunschwig, Mireille Vargas, Jennifer Keiser, Timothy J. Egan

, Kelly Chibale

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation

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Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge

, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz and 10 other authors

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

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All papers authored by Kelly Chibale