Gary Tresadern
0000-0002-4801-1644
Janssen (Belgium)
11 papers found
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Structural basis for the oligomerization-facilitated NLRP3 activation
Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders
[1,2,4]Triazolo[1,5-a]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration
Application of the ESMACS Binding Free Energy Protocol to a Multi‐Binding Site Lactate Dehydogenase A Ligand Dataset
Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu2 Receptor PAMs
Application of ESMACS binding free energy protocols to diverse datasets: Bromodomain-containing protein 4
Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442
Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor
Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization
Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches
Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study
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