All papers authored by Patrick Sexton
Refreshing results…
2023
Wessel A. C. Burger 
,
Vi Pham,
Ziva Vuckovic,
Alexander S. Powers,
Jesse I. Mobbs ,
Yianni Laloudakis,
Alisa Glukhova ,
Denise Wootten ,
Andrew B. Tobin ,
Patrick M. Sexton ,
Steven M. Paul,
Christian C. Felder,
Radostin Danev ,
Ron O. Dror ,
Arthur Christopoulos
and 2 other authors
,
Vi Pham,
Ziva Vuckovic,
Alexander S. Powers,
Jesse I. Mobbs ,
Yianni Laloudakis,
Alisa Glukhova ,
Denise Wootten ,
Andrew B. Tobin ,
Patrick M. Sexton ,
Steven M. Paul,
Christian C. Felder,
Radostin Danev ,
Ron O. Dror ,
Arthur Christopoulos
and 2 other authors
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
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Alexander S. Powers,
Vi Pham,
Wessel A. C. Burger ,
Geoff Thompson,
Yianni Laloudakis,
Nicholas W. Barnes,
Patrick M. Sexton ,
Steven M. Paul,
Arthur Christopoulos ,
David M. Thal ,
Christian C. Felder,
Celine Valant ,
Ron O. Dror
,
Geoff Thompson,
Yianni Laloudakis,
Nicholas W. Barnes,
Patrick M. Sexton ,
Steven M. Paul,
Arthur Christopoulos ,
David M. Thal ,
Christian C. Felder,
Celine Valant ,
Ron O. Dror
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs
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Alexander S. Powers,
Vi Pham,
Wessel A. C. Burger ,
Geoff Thompson,
Yianni Laloudakis,
Nicholas W. Barnes,
Patrick M. Sexton ,
Steven M. Paul,
Arthur Christopoulos ,
David M. Thal ,
Christian C. Felder,
Celine Valant ,
Ron O. Dror
,
Geoff Thompson,
Yianni Laloudakis,
Nicholas W. Barnes,
Patrick M. Sexton ,
Steven M. Paul,
Arthur Christopoulos ,
David M. Thal ,
Christian C. Felder,
Celine Valant ,
Ron O. Dror
Structural basis of efficacy-driven ligand selectivity at GPCRs
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2022
Huong T. M. Nguyen,
Emma T. van der Westhuizen ,
Christopher J. Langmead ,
Andrew B. Tobin ,
Patrick M. Sexton ,
Arthur Christopoulos ,
Celine Valant
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,
Christopher J. Langmead ,
Andrew B. Tobin ,
Patrick M. Sexton ,
Arthur Christopoulos ,
Celine Valant
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Louis Dwomoh ,
Mario Rossi ,
Miriam Scarpa,
Elham Khajehali,
Colin Molloy ,
Pawel Herzyk,
Shailesh N. Mistry ,
Andrew R. Bottrill ,
Patrick M. Sexton ,
Arthur Christopoulos ,
P. Jeffrey Conn ,
Craig W. Lindsley ,
Sophie J. Bradley ,
Andrew B. Tobin
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,
Mario Rossi ,
Miriam Scarpa,
Elham Khajehali,
Colin Molloy ,
Pawel Herzyk,
Shailesh N. Mistry ,
Andrew R. Bottrill ,
Patrick M. Sexton ,
Arthur Christopoulos ,
P. Jeffrey Conn ,
Craig W. Lindsley ,
Sophie J. Bradley ,
Andrew B. Tobin
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Giuseppe Deganutti ,
Yi-Lynn Liang,
Xin Zhang,
Maryam Khoshouei,
Lachlan Clydesdale,
Matthew J. Belousoff,
Hari Venugopal ,
Tin T. Truong,
Alisa Glukhova ,
Andrew N. Keller,
Karen J. Gregory ,
Katie Leach ,
Arthur Christopoulos ,
Radostin Danev ,
Christopher A. Reynolds
and 3 other authors
,
Yi-Lynn Liang,
Xin Zhang,
Maryam Khoshouei,
Lachlan Clydesdale,
Matthew J. Belousoff,
Hari Venugopal ,
Tin T. Truong,
Alisa Glukhova ,
Andrew N. Keller,
Karen J. Gregory ,
Katie Leach ,
Arthur Christopoulos ,
Radostin Danev ,
Christopher A. Reynolds
and 3 other authors
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
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2021
Christopher J. Draper-Joyce ,
Rebecca Bhola,
Jinan Wang ,
Apurba Bhattarai,
Anh T. N. Nguyen ,
India Cowie-Kent,
Kelly O’Sullivan ,
Ling Yeong Chia,
Hariprasad Venugopal ,
Celine Valant ,
David M. Thal ,
Denise Wootten,
Nicolas Panel ,
Jens Carlsson,
Macdonald J. Christie
and 9 other authors
,
Rebecca Bhola,
Jinan Wang ,
Apurba Bhattarai,
Anh T. N. Nguyen ,
India Cowie-Kent,
Kelly O’Sullivan ,
Ling Yeong Chia,
Hariprasad Venugopal ,
Celine Valant ,
David M. Thal ,
Denise Wootten,
Nicolas Panel ,
Jens Carlsson,
Macdonald J. Christie
and 9 other authors
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
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Wessel A. C. Burger ,
Patrick R. Gentry,
Alice E. Berizzi,
Ziva Vuckovic,
Emma T. van der Westhuizen,
Geoff Thompson,
Mahmuda Yeasmin,
Craig W. Lindsley ,
Patrick M. Sexton ,
Christopher J. Langmead ,
Andrew B. Tobin ,
Arthur Christopoulos,
Celine Valant ,
David M. Thal
,
Patrick R. Gentry,
Alice E. Berizzi,
Ziva Vuckovic,
Emma T. van der Westhuizen,
Geoff Thompson,
Mahmuda Yeasmin,
Craig W. Lindsley ,
Patrick M. Sexton ,
Christopher J. Langmead ,
Andrew B. Tobin ,
Arthur Christopoulos,
Celine Valant ,
David M. Thal
Identification of a Novel Allosteric Site at the M5Muscarinic Acetylcholine Receptor
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Jesse I. Mobbs ,
Matthew J. Belousoff ,
Kaleeckal G. Harikumar,
Sarah J. Piper ,
Xiaomeng Xu ,
Sebastian G. B. Furness ,
Hari Venugopal ,
Arthur Christopoulos ,
Radostin Danev ,
Denise Wootten,
David M. Thal ,
Laurence J. Miller ,
Patrick M. Sexton
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,
Matthew J. Belousoff ,
Kaleeckal G. Harikumar,
Sarah J. Piper ,
Xiaomeng Xu ,
Sebastian G. B. Furness ,
Hari Venugopal ,
Arthur Christopoulos ,
Radostin Danev ,
Denise Wootten,
David M. Thal ,
Laurence J. Miller ,
Patrick M. Sexton
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Tracy M. Josephs ,
Matthew J. Belousoff ,
Yi-Lynn Liang ,
Sarah J. Piper ,
Jianjun Cao ,
Daniel J. Garama ,
Katie Leach ,
Karen J. Gregory ,
Arthur Christopoulos ,
Debbie L. Hay ,
Radostin Danev ,
Denise Wootten ,
Patrick M. Sexton
,
Matthew J. Belousoff ,
Yi-Lynn Liang ,
Sarah J. Piper ,
Jianjun Cao ,
Daniel J. Garama ,
Katie Leach ,
Karen J. Gregory ,
Arthur Christopoulos ,
Debbie L. Hay ,
Radostin Danev ,
Denise Wootten ,
Patrick M. Sexton
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms
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Maoqing Dong,
Giuseppe Deganutti ,
Sarah J. Piper ,
Yi-Lynn Liang,
Maryam Khoshouei,
Matthew J. Belousoff,
Kaleeckal G. Harikumar,
Christopher A. Reynolds ,
Alisa Glukhova ,
Sebastian G. B. Furness ,
Arthur Christopoulos,
Radostin Danev ,
Denise Wootten,
Patrick M. Sexton ,
Laurence J. Miller
,
Sarah J. Piper ,
Yi-Lynn Liang,
Maryam Khoshouei,
Matthew J. Belousoff,
Kaleeckal G. Harikumar,
Christopher A. Reynolds ,
Alisa Glukhova ,
Sebastian G. B. Furness ,
Arthur Christopoulos,
Radostin Danev ,
Denise Wootten,
Patrick M. Sexton ,
Laurence J. Miller
Structure and dynamics of the active Gs-coupled human secretin receptor
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Michael L. Garelja,
Maggie Au,
Margaret A. Brimble ,
Joseph J. Gingell,
Erica R. Hendrikse ,
Annie Lovell,
Nicole Prodan,
Patrick M. Sexton ,
Andrew Siow,
Christopher S. Walker,
Harriet A. Watkins,
Geoffrey M. Williams,
Denise Wootten,
Sung H. Yang,
Paul W. R. Harris
and 1 other authors
,
Joseph J. Gingell,
Erica R. Hendrikse ,
Annie Lovell,
Nicole Prodan,
Patrick M. Sexton ,
Andrew Siow,
Christopher S. Walker,
Harriet A. Watkins,
Geoffrey M. Williams,
Denise Wootten,
Sung H. Yang,
Paul W. R. Harris
and 1 other authors
Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors
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2019
Ziva Vuckovic,
Patrick R. Gentry,
Alice E. Berizzi,
Kunio Hirata,
Swapna Varghese,
Geoff Thompson,
Emma T. van der Westhuizen,
Wessel A. C. Burger,
Raphaël Rahmani,
Celine Valant ,
Christopher J. Langmead,
Craig W. Lindsley,
Jonathan B. Baell,
Andrew B. Tobin,
Patrick M. Sexton
and 2 other authors
,
Christopher J. Langmead,
Craig W. Lindsley,
Jonathan B. Baell,
Andrew B. Tobin,
Patrick M. Sexton
and 2 other authors
Crystal structure of the M 5 muscarinic acetylcholine receptor
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Scott A. Hollingsworth ,
Brendan Kelly ,
Celine Valant ,
Jordan Arthur Michaelis,
Olivia Mastromihalis,
Geoff Thompson,
A. J. Venkatakrishnan,
Samuel Hertig,
Peter J. Scammells,
Patrick M. Sexton ,
Christian C. Felder,
Arthur Christopoulos,
Ron O. Dror
,
Brendan Kelly ,
Celine Valant ,
Jordan Arthur Michaelis,
Olivia Mastromihalis,
Geoff Thompson,
A. J. Venkatakrishnan,
Samuel Hertig,
Peter J. Scammells,
Patrick M. Sexton ,
Christian C. Felder,
Arthur Christopoulos,
Ron O. Dror
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
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Emma dal Maso,
E. Dal Maso,
Emma dal Maso,
Alisa Glukhova ,
Yue Zhu,
Javier Garcia-Nafria,
Christopher G. Tate,
Silvia Atanasio,
Christopher A. Reynolds,
Erney Ramírez-Aportela,
Jose-Maria Carazo ,
Caroline A. Hick,
Sebastian G. B. Furness ,
Debbie L. Hay ,
Yi-Lynn Liang
and 5 other authors
,
Yue Zhu,
Javier Garcia-Nafria,
Christopher G. Tate,
Silvia Atanasio,
Christopher A. Reynolds,
Erney Ramírez-Aportela,
Jose-Maria Carazo ,
Caroline A. Hick,
Sebastian G. B. Furness ,
Debbie L. Hay ,
Yi-Lynn Liang
and 5 other authors
The Molecular Control of Calcitonin Receptor Signaling
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2018
Manuela Jörg ,
Emma T. van der Westhuizen,
Elham Khajehali,
Wessel A. C. Burger,
Jonathan M. White ,
Kwok H. C. Choy,
Andrew B. Tobin ,
Patrick M. Sexton ,
Celine Valant ,
Ben Capuano ,
Arthur Christopoulos,
Peter J. Scammells
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,
Emma T. van der Westhuizen,
Elham Khajehali,
Wessel A. C. Burger,
Jonathan M. White ,
Kwok H. C. Choy,
Andrew B. Tobin ,
Patrick M. Sexton ,
Celine Valant ,
Ben Capuano ,
Arthur Christopoulos,
Peter J. Scammells
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