All papers authored by David Root
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Jan Philipp Novotny ,
Doga C. Gulhan ,
Isabella Klooster ,
Antuan V. Tran ,
Macy Kasbo ,
Meijun Z. Lundberg ,
Wen-Bin Ou ,
Derrick L. Tao ,
Daniel F. Pilco-Janeta ,
Victor Y. Mao ,
Frank T. Zenke ,
Brittaney A. Leeper ,
Prafulla C. Gokhale ,
Glenn S. Cowley
and 7 other authors
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R. Taylor Durall ,
Nhi M. Luong ,
Hans J. Hertzler ,
Julianna Huang ,
Prafulla C. Gokhale ,
Brittaney A. Leeper ,
Nicole S. Persky ,
David E. Root ,
Praju V. Anekal ,
Paula D. L. M. Montero Llopis ,
Clement N. David ,
Jeffery L. Kutok ,
Alejandra Raimondi ,
Karan Saluja
and 11 other authors
EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes
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Mathias J. Wawer ,
Amy Goodale,
Yenarae Lee,
Mariya Kazachkova,
Joshua M. Dempster ,
Sandrine Muller,
Joan Levy,
Daniel M. Freed,
Josh Sommer,
Jérémie Kalfon,
Francisca Vazquez,
William C. Hahn ,
David E. Root ,
Paul A. Clemons
and 1 other authors
Mapping the landscape of genetic dependencies in chordoma
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Tsukasa Shibue ,
Ashir A. Borah ,
Benjamin Gaeta ,
Linh He ,
Lisa Leung ,
Naomi Li ,
Sydney M. Moyer ,
Brian H. Shim ,
Nancy Dumont ,
Alfredo Gonzalez ,
Nolan R. Bick ,
Mariya Kazachkova ,
Joshua M. Dempster ,
John Michael Krill-Burger
and 8 other authors
A ubiquitination cascade regulating the integrated stress response and survival in carcinomas
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Sarah Kate Lane-Reticker,
Emily A. Kessler,
Audrey J. Muscato ,
Arnav Mehta,
Samuel S. Freeman ,
Peter M. Allen,
Kira E. Olander ,
Kyle M. Ockerman ,
Clara H. Wolfe,
Fabius Wiesmann,
Nelson H. Knudsen ,
Hsiao-Wei Tsao,
Arvin Iracheta-Vellve
and 18 other authors
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
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Lucy C. Young,
Alvaro J. Amor,
James R. Fuller ,
Cara V. Fraley,
Abbey M. Sykes,
Jonathan So,
Joshua Pan,
Laura Baker,
Sun Joo Lee,
Douglas B. Wheeler,
David L. Mayhew,
Nicole S. Persky
and 10 other authors
Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex
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Adhana Asfaw,
Michael V. Rothberg,
Thomas A. Skipper,
Carly Langan,
Gabriel Mesa,
Alfredo Gonzalez ,
Lauren E. Surface,
Kentaro Ito,
Mariya Kazachkova,
William N. Colgan ,
Allison Warren,
Joshua M. Dempster ,
John M. Krill-Burger
and 15 other authors
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Lisa Brenan,
Mariana do Carmo,
Patrick Duggan,
Besnik Bajrami,
Michael Arciprete,
Andrew Boghossian ,
Emma Vaimberg,
Steven J. Ferrara,
Timothy A. Lewis,
Danny Rosenberg,
Tenzin Sangpo,
Jennifer A. Roth,
Virendar K. Kaushik,
Federica Piccioni
and 3 other authors
Systematic identification of biomarker-driven drug combinations to overcome resistance
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Zachary J. Reitman,
Sophie Lu,
Graham Buchan,
Gabrielle Gionet,
Frank Dubois,
Diana M. Carvalho ,
Juliann Shih ,
Shu Zhang,
Noah F. Greenwald,
Travis Zack,
Ofer Shapira,
Kristine Pelton,
Rachel Hartley,
Heather Bear
and 41 other authors
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
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Ruitong Li,
Sidharth Jain ,
Andreas Wernitznig,
John M. Krill-Burger ,
Christopher T. Lemke,
Davide Monducci ,
Diego J. Rodriguez ,
Liang Chang,
Sanjukta Dutta ,
Debjani Pal ,
Brenton R. Paolella ,
Michael V. Rothberg ,
David E. Root
and 7 other authors
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Guillaume Kugener,
Alexandra B. Forman ,
Michael V. Rothberg ,
Mai Abdusamad,
Alfredo Gonzalez ,
Miljan Kuljanin,
Amanda L. Robichaud,
Amy Saur Conway,
Amy Saur Conway,
Joshua M. Dempster ,
Brenton R. Paolella,
Nancy Dumont ,
Volker Hovestadt
and 6 other authors
Selective modulation of a pan-essential protein as a therapeutic strategy in cancer
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Praveen Suraneni,
Hamza Celik,
Andrew Volk,
Qiang Jeremy Wen,
Te Ling ,
Marinka Bulic ,
Terra Lasho,
Richard P. Koche,
Christopher A. Famulare,
Noushin Farnoud,
Brady Stein,
Michael Schieber ,
Sandeep Gurbuxani,
David E. Root
and 10 other authors
LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms
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Li Wang,
Karolina Stumbraite,
Vickie M. Wang,
Ginevra Botta,
Nicholas J. Lyons,
Amy Goodale,
Zohra Kalani,
Briana Fritchman
and 11 other authors
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
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Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases
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Clare Pacini ,
Sasha Pantel,
Fiona M. Behan ,
Thomas Green,
John Krill-Burger ,
Charlotte M. Beaver,
Scott T. Younger,
Victor Zhivich,
Hanna Najgebauer,
Felicity Allen,
Emanuel Gonçalves,
Rebecca Shepherd,
John G. Doench ,
Kosuke Yusa
and 9 other authors
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets
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Peter G. Miller ,
Rohan Sharma ,
Marie McConkey ,
Matthew Leventhal ,
Andrei V. Krivtsov ,
Andrew O. Giacomelli ,
Waihay Wong ,
Jesi Kim ,
Sherry Chao,
Kari J. Kurppa,
Xiaoping Yang ,
Kirsten Milenkowic ,
Federica Piccioni ,
David E. Root
and 10 other authors
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies
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Gregory V. Kryukov,
Shuba Gopal,
Amy Deik,
Amanda Souza,
Kerry Pierce,
Paula Keskula,
Desiree Hernandez,
Julie Ann,
Dojna Shkoza,
Verena Apfel,
Yilong Zou ,
Francisca Vazquez
and 11 other authors
The landscape of cancer cell line metabolism
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Jesse S. Novak,
Aditi Gulati,
Elizabeth Buss,
Scott T. Younger,
Samuel K. McBrayer,
Glenn S. Cowley,
Dennis M. Bonal,
Quang-De Nguyen
and 14 other authors
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
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