Maree Smith
0000-0003-2281-3734
112 papers found
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The role of morphine-6-glucuronide (M6G) in pain control
Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats
Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites
Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management
Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis
Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats
Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection
Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma
Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation
The intrinsic antinociceptive effects of oxycodone appear to be κ-opioid receptor mediated:
Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways
Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide
Quantitative autoradiography of peripheral opioid binding sites in rat lung
Effects of morphine-3-glucuronide and morphine on the K+-evoked release of [3H]-glutamic acid and [14C]-gamma-aminobutyric acid from rat brain synaptosomes
Morphine-3-glucuronide: evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat:
Pharmacokinetics and Pharmacodynamics of Oxycodone when Given Intravenously and Rectally to Adult Patients with Cancer Pain:
Comments on Goucke et al., Pain, 56 (1994) 145–149:
Characterization of non-conventional opioid binding sites in rat and human lung
Quantitation of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Plasma and Cerebrospinal Fluid Using Solid-Phase Extraction and High-Performance Liquid Chromatography with Electrochemical Detection:
The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex
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