Charles Harrington

All papers authored by Charles Harrington

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2024 Mohammad Arastoo, Lewis K. Penny, Richard Lofthouse, Aya Abdallah, Anna Abrahamsson, Pietro Marini, Valeria Melis, Gernot Riedel, Charles R. Harrington

, Claude M. Wischik, Andrew Porter, Soumya Palliyil

High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

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Anna L. Cranston, Igor Kraev, Mike G. Stewart, David Horsley, Renato X. Santos, Lianne Robinson, Eline Dreesen, Paul Armstrong, Soumya Palliyil, Charles R. Harrington

, Claude M. Wischik, Gernot Riedel

Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine

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Karima Schwab

, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R. Harrington

, Claude M. Wischik, Grażyna Niewiadomska, Gernot Riedel

Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: Interference by cholinesterase inhibitors

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Lewis K. Penny

, Richard Lofthouse, Mohammad Arastoo, Andy Porter, Soumya Palliyil, Charles R. Harrington

, Claude M. Wischik

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer’s disease

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Karima Schwab

, Silke Frahm

, Mandy Magbagbeolu, David Horsley, Elizabeth A. Goatman, Valeria Melis

, Franz Theuring, Ahtsham Ishaq, John M. D. Storey, Charles R. Harrington, Claude M. Wischik

, Gernot Riedel

LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy

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Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R. Harrington

, Claude M. Wischik, Gernot Riedel, Grazyna Niewiadomska

Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer’s-like Tauopathy Mouse Model

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Karima Schwab

, Mandy Magbagbeolu, Franz Theuring, Charles R. Harrington

, Claude M. Wischik, Gernot Riedel

Solubility of α-synuclein species in the L62 mouse model of synucleinopathy

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Anne Anschuetz, Karima Schwab

, Charles R. Harrington

, Claude M. Wischik, Gernot Riedel

A Meta-Analysis on Presynaptic Changes in Alzheimer’s Disease

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Lianne Robinson

, Eline Dreesen, Miguel Mondesir, Charles Harrington

, Claude Wischik, Gernot Riedel

Apathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia

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2023 Mohammad Arastoo, Michael P. Mazanetz, Sonya Miller, Helen Shiells, Claire Hull

, Keith Robinson

, John M. D. Storey, Charles R. Harrington

, Claude M. Wischik

Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants

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Constantin Kondak, Michael Leith, Thomas C. Baddeley, Renato X. Santos

, Charles R. Harrington

, Claude M. Wischik, Gernot Riedel, Jochen Klein

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

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Alex Zabala-Findlay, Lewis K. Penny

, Richard A. Lofthouse, Andrew J. Porter, Soumya Palliyil, Charles R. Harrington

, Claude M. Wischik, Mohammad Arastoo

Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis

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2022 Youssra K. Al-Hilaly, Connor Hurt, Janet E. Rickard, Charles R. Harrington

, John M. D. Storey, Claude M. Wischik, Louise C. Serpell, Ansgar B. Siemer

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

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Youssra K. Al-Hilaly, Karen E. Marshall, Liisa Lutter, Luca Biasetti, Kurtis Mengham, Charles R. Harrington

, Wei-Feng Xue, Claude M. Wischik, Louise C. Serpell

An Additive-Free Model for Tau Self-Assembly

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Mahmoud B. Maina, Youssra K. Al-Hilaly, Sebastian Oakley, Gunasekhar Burra, Tahmida Khanom, Luca Biasetti, Kurtis Mengham, Karen Marshall, Charles R. Harrington

, Claude M. Wischik, Louise C. Serpell

Dityrosine Cross-links are Present in Alzheimer’s Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro

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Karima Schwab

, Zoi Chasapopoulou, Silke Frahm, Mandy Magbagbeolu, Anna Cranston, Charles R. Harrington

, Claude M. Wischik, Franz Theuring, Gernot Riedel

Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine

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Renato X. Santos

, Valeria Melis, Elizabeth A. Goatman, Michael Leith, Thomas C. Baddeley, John M. D. Storey, Gernot Riedel, Claude M. Wischik, Charles R. Harrington

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

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2021 Constantin Kondak, Gernot Riedel, Charles R. Harrington

, Claude M. Wischik, Jochen Klein

Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine

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Vesna Vuksanović

, Roger T. Staff, Suzannah Morson, Trevor Ahearn, Luc Bracoud, Alison D. Murray, Peter Bentham

, Christopher M. Kipps, Charles R. Harrington

, Claude M. Wischik

Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia

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Peter Bentham, Roger T. Staff, Bjoern O. Schelter, Helen Shiells, Charles R. Harrington

, Claude M. Wischik

Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier

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All papers authored by Charles Harrington