Christian Lehn Brand - Dissemin

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All papers authored by Christian Lehn Brand

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2024 Thomas Hoeg-Jensen

ORCID

ORCID

, Christian L. Brand

ORCID

ORCID

, Christian Fledelius, Peter K. Nielsen, Erica Nishimura

ORCID

, Alice R. Madsen

ORCID

, Lennart Lykke, Kim S. Halskov, Simona Koščová, S. Koscova, Vladislav Kotek, Anthony P. Davis

ORCID

, Robert A. Tromans

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and 19 other authors

Glucose-sensitive insulin with attenuation of hypoglycaemia

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2023 Christian Lehn Brand

ORCID

ORCID

Probing the mechanism of reduced in vivo potency of insulin detemir

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2022 Henning Hvid

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, Christian L. Brand

ORCID

, Tina Hummelshøj, Sanne Jensen, Stephan D. Bouman, Andrew Bowler, Bjarne R. Poulsen, Peter Tiainen, Thorbjörn Åkertröm, Damien Demozay, Thomas Hoeg-Jensen, Camilla Ingvorsen, Thomas Å. Pedersen, Jim McGuire, Thomas Egebjerg and 7 other authors

Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models

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Emilie Prang Nielsen

ORCID

, Søren Andersen, Christian Lehn Brand

ORCID

, Susanne Ditlevsen

Applying historical data in a nonlinear mixed-effects model can reduce the number of control rats required for calculation of the relative potency of insulin analogues

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2020 Frantisek Hubálek

ORCID

, Hanne H. F. Refsgaard, Sanne Gram-Nielsen

ORCID

ORCID

, Erica Nishimura

ORCID

, Martin Münzel

ORCID

, Christian Lehn Brand

ORCID

, Carsten Enggaard Stidsen

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, Christian Hove Claussen, Erik Max Wulff

ORCID

, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson

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and 12 other authors

Author Correction: Molecular engineering of safe and efficacious oral basal insulin

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2019 Thorbjorn Akerstrom, Daniel Goldman

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, Franciska Nilsson, Stephanie L. Milkovich, Graham M. Fraser

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, Christian Lehn Brand

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, Ylva Hellsten

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, Christopher G. Ellis

ORCID

Hyperinsulinemia does not cause de novo capillary recruitment in rat skeletal muscle

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Justin M. Gregory

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, Guillaume Kraft, Melanie F. Scott, Doss W. Neal, Ben Farmer, Marta S. Smith, Jon R. Hastings, Peter Madsen, Thomas B. Kjeldsen

ORCID

, Susanne Hostrup, Christian L. Brand

ORCID

, Christian Fledelius, Erica Nishimura, Alan D. Cherrington

Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs

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Dale S. Edgerton

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, Melanie Scott, Ben Farmer, Phillip E. Williams, Peter Madsen, Thomas Kjeldsen

ORCID

, Christian L. Brand

ORCID

, Christian Fledelius, Erica Nishimura, Alan D. Cherrington

Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery

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2015 Justin M. Gregory

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, Guillaume Kraft, Melanie F. Scott, Doss W. Neal, Ben Farmer, Marta S. Smith, Jon R. Hastings, Eric J. Allen, E. Patrick Donahue, Noelia Rivera, Jason J. Winnick, Dale S. Edgerton, Erica Nishimura, Christian Fledelius, Christian L. Brand

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and 1 other authors

Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes

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2014 Thorbjorn Akerstrom

ORCID

, Lasse Laub, Kenneth Vedel, Christian Lehn Brand

ORCID

, Bente Klarlund Pedersen, Anna Kaufmann Lindqvist, Jørgen F. P. Wojtaszewski

ORCID

, Ylva Hellsten

Increased skeletal muscle capillarization enhances insulin sensitivity

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C. Höfferer, D. Tutkur, C. Fledelius, C. L. Brand

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, T. J. Alsted, J. Damgaard, E. Nishimura, C. B. Jeppesen, S. I. Mautner, T. R. Pieber, F. Sinner

Open flow microperfusion: pharmacokinetics of human insulin and insulin detemir in the interstitial fluid of subcutaneous adipose tissue

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Dale S. Edgerton, Mary C. Moore, Jason J. Winnick, Melanie Scott, Ben Farmer, Helle Naver, Claus B. Jeppesen, Peter Madsen, Thomas B. Kjeldsen

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, Erica Nishimura, Christian L. Brand

ORCID

, Alan D. Cherrington

Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

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2010 A. R. Sørensen, C. E. Stidsen, U. Ribel, E. Nishimura, J. Sturis, I. Jonassen, S. D. Bouman, P. Kurtzhals, C. L. Brand

ORCID

Insulin detemir is a fully efficacious, low affinity agonist at the insulin receptor

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2009 Jérôme Ruzzin, Rasmus Petersen, Emmanuelle Meugnier, Lise Madsen

ORCID

, Erik-Jan Lock, Haldis Lillefosse, Tao Ma, Tao, Sandra Pesenti, Si Brask Sonne, Troels Torben Marstrand, Marian Kjellevold Malde, Zhen-Yu Du, Carine Chavey, Lluis Fajas and 5 other authors

Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome

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C. L. Brand

ORCID

, E. D. Galsgaard, D. Tornehave, J. Rømer, C. F. Gotfredsen, K. Wassermann, L. B. Knudsen, A. Vølund, J. Sturis

Synergistic effect of the human GLP-1 analogue liraglutide and a dual PPARα/γ agonist on glycaemic control in Zucker diabetic fatty rats

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Peter Madsen, János T. Kodra, Carsten Behrens, Erica Nishimura, Claus B. Jeppesen, Lone Pridal, Birgitte Andersen, Lotte B. Knudsen, Carmen Valcarce-Aspegren, Mette Guldbrandt, Inge T. Christensen, Anker S. Jørgensen, Lars Ynddal, Christian L. Brand

ORCID

, Morten A.-A. Bagger and 1 other authors

Human Glucagon Receptor Antagonists with Thiazole Cores. A Novel Series with Superior Pharmacokinetic Properties

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2008 Lauge Schäffer, Christian L. Brand

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, Bo F. Hansen, Ulla Ribel, Allan C. Shaw, Rita Slaaby, Jeppe Sturis

A novel high-affinity peptide antagonist to the insulin receptor

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János T. Kodra, Anker Steen Jørgensen, Birgitte Andersen, Carsten Behrens, Christian Lehn Brand

ORCID

, Inger Thøger Christensen, Mette Guldbrandt, Claus Bekker Jeppesen, Lotte B. Knudsen, Peter Madsen, Erica Nishimura, Christian Sams, Ulla G. Sidelmann, Raymon A. Pedersen, Francis C. Lynn and 1 other authors

Novel Glucagon Receptor Antagonists with Improved Selectivity over the Glucose-Dependent Insulinotropic Polypeptide Receptor

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P. J. Larsen, E. M. Wulff, C. F. Gotfredsen, C. L. Brand

ORCID

, J. Sturis, N. Vrang, L. B. Knudsen, K. Lykkegaard

Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats

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2007 M. Sörhede Winzell, M. Sörhede Winzell, C. L. Brand

ORCID

, N. Wierup, U. G. Sidelmann, F. Sundler, E. Nishimura, B. Ahrén

Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet

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