AbstractA ‘giant’ slip dynamics was engineered to a highly confined interface of a dewetting polymethylmethacrylate (PMMA) ultrathin film by introducing a lubricating viscous polystyrene (PS) sublayer. The crossover of regimes from no-slip to giant-slip was engendered by tuning the viscosity and thickness of the sublayer. A long-range hole-rim interaction with increase in slippage on the PMMA-PS interface transformed the circular holes on the PMMA surface into the noncircular faceted ones. The extent of the slippage and the transition of the length scales from slip-dominated to no-slip regime were evaluated using a general linear stability analysis. The proposed formulation provided an analytical tool to evaluate the slippage effective at the soft and deformable liquid-liquid interfaces.