Published in
American Society of Hematology, Blood, p. blood-2017-07-799270
DOI: 10.1182/blood-2017-07-799270
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Platelets from donors with consistently low HLA-B8, -B12, or -B35 expression do not undergo antibody-mediated internalization
Journal article published in 2018 by
Anno Saris,
Bert Tomson,
Anneke Brand,
Arend Mulder,
Frans H. Claas,
Jos Lorinser,
John Scharenberg,
S. Marieke van Ham,
Anja ten Brinke 
,
Jaap Jan Zwaginga,
Pieter F. van der Meer
,
Jaap Jan Zwaginga,
Pieter F. van der Meer
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Abstract
Key Points HLA-B8, -B12, or -B35 expression on platelets varies significantly between donors and in certain donors is consistently low or undetectable. Antibody-mediated internalization of platelets correlates with antigen expression and is absent in platelets with low HLA expression.