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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(54), p. 2262-2264, 2010

DOI: 10.1128/aac.01423-09

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Fast Standardized Therapeutic-Efficacy Assay for Drug Discovery against Tuberculosis

Journal article published in 2010 by Joaquín Rullas, Juan Ignacio Garcia ORCID, Manuela Beltran, Pere-Joan Cardona, N. Caceres, Neus Cáceres, José Francisco F. Garcia-Bustos ORCID, Iñigo Angulo-Barturen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Murine models of M ycobacterium tuberculosis infection are essential tools in drug discovery. Here we describe a fast standardized 9-day acute assay intended to measure the efficacy of drugs against M. tuberculosis growing in the lungs of immunocompetent mice. This assay is highly reproducible, allows good throughput, and was validated for drug lead optimization using isoniazid, rifampin, ethambutol, pyrazinamide, linezolid, and moxifloxacin.