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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(54), p. 2235-2238, 2010

DOI: 10.1128/aac.01665-09

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Trends in Antimicrobial Resistance of Acinetobacter baumannii Isolates from a Metropolitan Detroit Health System

Journal article published in 2010 by Tara Reddy, Teena Chopra, Dror Marchaim, Jason M. Pogue, George Alangaden, Hossein Salimnia, Dina Boikov, Shiri Navon-Venezia ORCID, Robert Akins, Philip Selman, Sorabh Dhar, Keith S. Kaye
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT A phenotypic and genotypic analysis of Acinetobacter baumannii was conducted from 2003 to 2008 in Detroit, MI. The incidence of A. baumannii increased from 1.7 to 3.7/1,000 patient days during the study period. Susceptibility to ampicillin-sulbactam and imipenem decreased from ∼90% to ∼40%. Genotyping revealed polyclonality, suggesting either emergence of multiple resistant strains or spread of a common genetic element. The sharp rise mandates major multidisciplinary interventions to optimize management of this multidrug-resistant pathogen.