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Cold Spring Harbor Laboratory Press, Genome Research, 11(18), p. 1778-1786, 2008

DOI: 10.1101/gr.082313.108

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Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex

Journal article published in 2008 by Diego Ottaviani, Elliott Lever, Richard Mitter, Tania Jones ORCID, Tim Forshew ORCID, Rossitza Christova, Eleni M. Tomazou, Vardhman K. Rakyan, Stephen A. Krawetz, Adrian E. Platts, Badmavady Segarane, Stephan Beck, Denise Sheer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The folding of chromatin into topologically constrained loop domains is essential for genomic function. We have identified genomic anchors that define the organization of chromatin loop domains across the human major histocompatibility complex (MHC). This locus contains critical genes for immunity and is associated with more diseases than any other region of the genome. Classical MHC genes are expressed in a cell type-specific pattern and can be induced by cytokines such as interferon-gamma (IFNG). Transcriptional activation of the MHC was associated with a reconfiguration of chromatin architecture resulting from the formation of additional genomic anchors. These findings suggest that the dynamic arrangement of genomic anchors and loops plays a role in transcriptional regulation.