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Elsevier, Current Opinion in Immunology, 2(24), p. 173-177

DOI: 10.1016/j.coi.2011.12.001

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The many roles of TOX in the immune system

Journal article published in 2011 by Parinaz Aliahmad, Akop Seksenyan, Jonathan Kaye ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

TOX is a member of an evolutionarily conserved DNA-binding protein family and is expressed in several immune-relevant cell subsets. Here, we review the key role of TOX in regulating development of CD4 T cells, natural killer cells and lymphoid tissue inducer cells, the latter responsible for the generation of lymph nodes. Although the exact molecular mechanism of action of TOX remains to be elucidated, the role of TOX in establishment of gene programs in the thymus and the potential of TOX as a regulator of E protein activity are discussed.