Published in
American Society for Microbiology, Infection and Immunity, 9(72), p. 5515-5521, 2004
DOI: 10.1128/iai.72.9.5515-5521.2004
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- [europepmc.org] | PDF
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- [www.ncbi.nlm.nih.gov] | PDF
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The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites
Journal article published in 2004 by
K. Rajeshwari,
Kalpesh Patel,
Savithri Nambeesan,
Monika Mehta 
,
Alfica Sehgal,
Tirtha Chakraborty,
Shobhona Sharma
,
Alfica Sehgal,
Tirtha Chakraborty,
Shobhona Sharma
This paper is made freely available by the publisher.
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Abstract
ABSTRACT Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum . Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.